Interleukin-10 in cancer immunotherapy: from bench to bedside

被引：55

作者：

Salkeni, Mohamad Adham ^{[1
]}

Naing, Aung ^{[2
]}

机构：

[1] NCI, Div Canc Treatment & Diag, Dev Therapeut Clin, Bethesda, MD USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Houston, TX 77030 USA

来源：

TRENDS IN CANCER | 2023年 / 9卷 / 09期

基金：

美国国家卫生研究院;

关键词：

RECOMBINANT HUMAN INTERLEUKIN-10; INFLAMMATORY-BOWEL-DISEASE; CD8(+) T-CELLS; SERUM INTERLEUKIN-18; CYTOKINE PRODUCTION; IL-10; ANTIGEN; MICE; PEGILODECAKIN; INTERFERON;

D O I：

10.1016/j.trecan.2023.05.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interleukin (IL)-10 was one of the first cytokines to be recognized. However, its functionality in promoting antitumor immunity was described more recently. Context-and concentration-dependent biological effects are the hallmarks of the pleiotropic role of IL-10. Despite reducing tumor-promoting inflammation, IL-10 may have a role in rejuvenating exhausted tumor-resident T cells. Contrary to the assumption that IL-10 produces an immunosuppressive tumor microenvi-ronment (TME), it promotes activation of tumor-resident CD8+ T cells, which aids tumor rejection. Emerging data from published early-Phase trials have shown mixed results in different tumor types. In this review, we summarize the biological effects of IL-10 and highlight the clinical experience using pegilodecakin.

引用

页码：716 / 725

页数：10

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