A molecularly imprinted electrochemical sensor with dual functional monomers for selective determination of gatifloxacin

被引：18

作者：

Huang, Yan ^{[1
]}

Sun, Xuyuan ^{[1
]}

Yang, Jing ^{[1
]}

Cao, Zhiyuan ^{[1
]}

Wang, Rujie ^{[1
]}

Li, Li ^{[1
]}

Ding, Yaping ^{[1
,2
]}

机构：

[1] Shanghai Univ, Coll Sci, Dept Chem, Shanghai 200444, Peoples R China

[2] Shanghai Univ, Shanghai Key Lab High Temp Supercond, Shanghai 200444, Peoples R China

来源：

MICROCHIMICA ACTA | 2023年 / 190卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Molecularly imprinted polymer; Electrochemical sensor; Differential pulse voltammetry; Dual functional monomers; Gatifloxacin;

D O I：

10.1007/s00604-023-05839-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A molecularly imprinted electrochemical sensor was designed for the selective determination of gatifloxacin (GTX) based on dual functional monomers. Multi-walled carbon nanotube (MWCNT) enhanced the current intensity and zeolitic imidazolate framework 8 (ZIF8) provided a large surface area to produce more imprinted cavities. In the electropolymerization of molecularly imprinted polymer (MIP), p-aminobenzoic acid (p-ABA) and nicotinamide (NA) were used as dual functional monomers, and GTX was the template molecule. Taking [Fe(CN)(6)](3-/4-) as an electrochemical probe, an oxidation peak on the glassy carbon electrode was located at about 0.16 V (vs. saturated calomel electrode). Due to the diverse interactions among p-ABA, NA, and GTX, the MIP-dual sensor exhibited higher specificity towards GTX than MIP-p-ABA and MIP-NA sensors. The sensor had a wide linear range from 1.00 x 10(-14) to 1.00 x 10(-7) M with a low detection limit of 2.61 x 10(-15) M. Satisfactory recovery between 96.5 and 105% with relative standard deviation from 2.4 to 3.7% in real water samples evidenced the potential of the method in antibiotic contaminant determination.

引用

页数：8

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