Intratumoral co-injections of NK cells and neutralizing antibodies against the NKG2A inhibitory pathway achieve efficacious anti-tumor responses in a CD8 T cell and cDC1-dependent manner

被引：0
|
作者：
Alvarez, Maite
Ochoa, Maria C.
Molina, Carmen
Teijeira, Alvaro
Garasa, Saray
Sanchez-Gregorio, Sandra
Olivera, Irene
Glez-Vaz, Javier
Cirella, Asunta
Gomis, Gabriel
Gonzalez-Gomariz, Jose
Berraondo, Pedro
Melero, Ignacio
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-2915
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2915
引用
收藏
页数：2
相关论文
共 5 条
  • [1] Targeting NKG2A to boost anti-tumor CD8 T-cell responses in human colorectal cancer
    Ducoin, Kathleen
    Oger, Romain
    Mutala, Linda Bilonda
    Deleine, Cecile
    Jouand, Nicolas
    Desfrancois, Juliette
    Podevin, Juliette
    Duchalais, Emilie
    Cruard, Jonathan
    Benlalam, Houssem
    Labarriere, Nathalie
    Bossard, Celine
    Jarry, Anne
    Gervois-Segain, Nadine
    ONCOIMMUNOLOGY, 2022, 11 (01):
  • [2] TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responses
    Harris, Rebecca
    Mammadli, Mahinbanu
    Hiner, Shannon
    Suo, Liye
    Yang, Qi
    Sen, Jyoti Misra
    Karimi, Mobin
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2023, 72 (06) : 1581 - 1601
  • [3] TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responses
    Rebecca Harris
    Mahinbanu Mammadli
    Shannon Hiner
    Liye Suo
    Qi Yang
    Jyoti Misra Sen
    Mobin Karimi
    Cancer Immunology, Immunotherapy, 2023, 72 : 1581 - 1601
  • [4] SO-C101 displays strong anti-tumor effect in TC-1 and TRAMP-C2 tumor mice and in combination with PD-1 blockade prevents tumor development in a NK and CD8+ T cells dependent manner
    Adkins, Irena
    Mikyskova, Romana
    Hradilova, Nada
    de Martynoff, Guy
    Bechard, David
    Moebius, Ulrich
    Reinis, Milan
    Spisek, Radek
    CANCER RESEARCH, 2020, 80 (16)
  • [5] In situ anti-tumor immunization using the tumor microenvironment reprograming with a TLR4-agonist induces strong CD4 and CD8 T cells responses, long-living T cell memory, and protection against 4T1 metastatic breast cancer in mice
    Ushakova, E.
    Savchenko, M.
    Lebedeva, E.
    Pichugin, A.
    Ataullakhanov, R.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2021, 51 : 391 - 391
1