Colorectal cancer: Review of signaling pathways and associated therapeutic strategies

被引：8

作者：

Leiphrakpam, Premila D. ^{[1
,2
]}

Rajappa, Senthil J. ^{[3
]}

Krishnan, Mridula ^{[4
]}

Batra, Rishi ^{[5
]}

Murthy, Shilpa S. ^{[6
]}

Are, Chandrakanth ^{[1
,2
,7
]}

机构：

[1] Univ Nebraska Med Ctr, Coll Med, Grad Med Educ, Omaha, NE USA

[2] Univ Nebraska Med Ctr, Coll Med, Dept Surg, Div Surg Oncol, Omaha, NE USA

[3] Basavatarakam Indo Amer Canc Hosp, Med Oncol, Hyderabad, Telangana, India

[4] Univ Nebraska Med Ctr, Coll Med, Dept Internal Med, Div Oncol & Hematol, Omaha, NE USA

[5] Univ Nebraska Med Ctr, Coll Med, Dept Surg, Div Gen Surg, Omaha, NE USA

[6] Mem Sloan Kettering Canc Ctr, Div Surg Oncol, Global Canc Dispar Initiat, New York, NY USA

[7] Univ Nebraska Med Ctr, Coll Med, Dept Surg, Div Surg Oncol, Omaha, NE 68198 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2023年 / 127卷 / 08期

关键词：

biomarkers; colorectal cancer; targeted therapy; RANDOMIZED PHASE-III; FOLFIRI PLUS BEVACIZUMAB; MOLECULAR SUBGROUP ANALYSES; FACTOR-BETA RECEPTOR; KRAS WILD-TYPE; OPEN-LABEL; 1ST-LINE TREATMENT; FOLFOXIRI PLUS; DOUBLE-BLIND; MAINTENANCE TREATMENT;

D O I：

10.1002/jso.27295

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor profiling and targeted therapy revolutionized the treatment strategies of metastatic colorectal cancer (mCRC) in the last decade. The heterogeneity of CRC tumors plays a critical role in the development of treatment resistance, which underscores the need to understand the molecular mechanism involved in CRC to develop novel targeted therapeutic strategies. This review provides an overview of the signaling pathways driving CRC, the existing targeted agents, their limitations, and future trends.

引用

页码：1277 / 1295

页数：19

共 50 条

[41] Signaling Pathways and Therapeutic Strategies in Advanced Basal Cell Carcinoma
Vallini, Giulia
Calabrese, Laura
Canino, Costanza
Trovato, Emanuele
Gentileschi, Stefano
Rubegni, Pietro
Tognetti, Linda
CELLS, 2023, 12 (21)
[42] Emerging therapeutic strategies targeting bone signaling pathways in periodontitis
Valverde, Araceli
George, Anne
Nares, Salvador
Naqvi, Afsar R.
JOURNAL OF PERIODONTAL RESEARCH, 2025, 60 (02) : 101 - 120
[43] Signaling pathways and targeted therapeutic strategies for polycystic ovary syndrome
Wang, Kexin
Li, Yanhua
FRONTIERS IN ENDOCRINOLOGY, 2023, 14
[44] The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer
Hon, Kha Wai
Abidin, Syafiq Asnawi Zainal
Othman, Iekhsan
Naidu, Rakesh
FRONTIERS IN PHARMACOLOGY, 2021, 12
[45] Therapeutic strategies targeting the epidermal growth factor receptor signaling pathway in metastatic colorectal cancer
Zhou, Yi
Wu, Shuang
Qu, Fan-Jie
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2024, 16 (06) : 2362 - 2379
[46] Recent advances in cancer-associated fibroblast: Biomarkers, signaling pathways, and therapeutic opportunities
Zhou Donger
Zheng Lei
中华医学杂志英文版, 2024, 137 (06)
[47] Recent advances in cancer-associated fibroblast: Biomarkers, signaling pathways, and therapeutic opportunities
Zhou, Donger
Zheng, Lei
CHINESE MEDICAL JOURNAL, 2024, 137 (06) : 638 - 650
[48] Potential signaling pathways as therapeutic targets for overcoming chemoresistance in mucinous ovarian cancer (Review)
Niiro, Emiko
Morioka, Sachiko
Iwai, Kana
Yamada, Yuki
Ogawa, Kenji
Kawahara, Naoki
Kobayashi, Hiroshi
BIOMEDICAL REPORTS, 2018, 8 (03) : 215 - 223
[49] Role played by MDSC in colitis-associated colorectal cancer and potential therapeutic strategies
Wang, Kang
Wang, Yun
Yin, Kai
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2024, 150 (05)
[50] A Review on Notch Signaling and Colorectal Cancer
Tyagi, Ashish
Sharma, Arun K.
Damodaran, Chendil
CELLS, 2020, 9 (06)

← 1 2 3 4 5 →