Colorectal cancer: Review of signaling pathways and associated therapeutic strategies

被引：11

作者：

Leiphrakpam, Premila D. ^{[1
,2
]}

Rajappa, Senthil J. ^{[3
]}

Krishnan, Mridula ^{[4
]}

Batra, Rishi ^{[5
]}

Murthy, Shilpa S. ^{[6
]}

Are, Chandrakanth ^{[1
,2
,7
]}

机构：

[1] Univ Nebraska Med Ctr, Coll Med, Grad Med Educ, Omaha, NE USA

[2] Univ Nebraska Med Ctr, Coll Med, Dept Surg, Div Surg Oncol, Omaha, NE USA

[3] Basavatarakam Indo Amer Canc Hosp, Med Oncol, Hyderabad, Telangana, India

[4] Univ Nebraska Med Ctr, Coll Med, Dept Internal Med, Div Oncol & Hematol, Omaha, NE USA

[5] Univ Nebraska Med Ctr, Coll Med, Dept Surg, Div Gen Surg, Omaha, NE USA

[6] Mem Sloan Kettering Canc Ctr, Div Surg Oncol, Global Canc Dispar Initiat, New York, NY USA

[7] Univ Nebraska Med Ctr, Coll Med, Dept Surg, Div Surg Oncol, Omaha, NE 68198 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2023年 / 127卷 / 08期

关键词：

biomarkers; colorectal cancer; targeted therapy; RANDOMIZED PHASE-III; FOLFIRI PLUS BEVACIZUMAB; MOLECULAR SUBGROUP ANALYSES; FACTOR-BETA RECEPTOR; KRAS WILD-TYPE; OPEN-LABEL; 1ST-LINE TREATMENT; FOLFOXIRI PLUS; DOUBLE-BLIND; MAINTENANCE TREATMENT;

D O I：

10.1002/jso.27295

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor profiling and targeted therapy revolutionized the treatment strategies of metastatic colorectal cancer (mCRC) in the last decade. The heterogeneity of CRC tumors plays a critical role in the development of treatment resistance, which underscores the need to understand the molecular mechanism involved in CRC to develop novel targeted therapeutic strategies. This review provides an overview of the signaling pathways driving CRC, the existing targeted agents, their limitations, and future trends.

引用

页码：1277 / 1295

页数：19

共 98 条

[1] WNT signalling pathways as therapeutic targets in cancer [J].

Anastas, Jamie N. ;

Moon, Randall T. .

NATURE REVIEWS CANCER, 2013, 13 (01) :11-26

[2] Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast Cancer [J].

Andre, Fabrice ;

Ciruelos, Eva ;

Rubovszky, Gabor ;

Campone, Mario ;

Loibl, Sibylle ;

Rugo, Hope S. ;

Iwata, Hiroji ;

Conte, Pierfranco ;

Mayer, Ingrid A. ;

Kaufman, Bella ;

Yamashita, Toshinari ;

Lu, Yen-Shen ;

Inoue, Kenichi ;

Takahashi, Masato ;

Papai, Zsuzsanna ;

Longin, Anne-Sophie ;

Mills, David ;

Wilke, Celine ;

Hirawat, Samit ;

Juric, Dejan .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (20) :1929-1940

[3] Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer [J].

Andre, T. ;

Shiu, K-K ;

Kim, T. W. ;

Jensen, B., V ;

Jensen, L. H. ;

Punt, C. ;

Smith, D. ;

Garcia-Carbonero, R. ;

Benavides, M. ;

Gibbs, P. ;

de la Fouchardiere, C. ;

Rivera, F. ;

Elez, E. ;

Bendell, J. ;

Le, D. T. ;

Yoshino, T. ;

Van Cutsem, E. ;

Yang, P. ;

Farooqui, M. Z. H. ;

Marinello, P. ;

Diaz, L. A., Jr. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (23) :2207-2218

[4] Final overall survival for the phase III KN177 study: Pembrolizumab versus chemotherapy in microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC). [J].

Andre, Thierry ;

Shiu, Kai-Keen ;

Kim, Tae Won ;

Jensen, Benny Vittrup ;

Jensen, Lars Henrik ;

Punt, Cornelis J. A. ;

Smith, Denis Michel ;

Garcia-Carbonero, Rocio ;

Alcaide, Julia ;

Gibbs, Peter ;

De la Fouchardiere, Christelle ;

Rivera, Fernando ;

Elez, Elena ;

Bendell, Johanna C. ;

Le, Dung T. ;

Yoshino, Takayuki ;

Zhong, Wen Yan ;

Fogelman, David R. ;

Marinello, Patricia ;

Diaz, Luis A. .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)

[5] Bevacizumab Maintenance Versus No Maintenance During Chemotherapy-Free Intervals in Metastatic Colorectal Cancer: A Randomized Phase III Trial (PRODIGE 9) [J].

Aparicio, Thomas ;

Ghiringhelli, Francois ;

Boige, Valerie ;

Le Malicot, Karine ;

Taieb, Julien ;

Bouche, Olivier ;

Phelip, Jean-Marc ;

Francois, Eric ;

Borel, Christian ;

Faroux, Roger ;

Dahan, Laetitia ;

Jacquot, Stephane ;

Genet, Dominique ;

Khemissa, Faiza ;

Suc, Etienne ;

Desseigne, Francoise ;

Texereau, Patrick ;

Lepage, Come ;

Bennouna, Jaafar .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (07) :674-+

[6] Role of ErbB Receptors in Cancer Cell Migration and Invasion [J].

Appert-Collin, Aline ;

Hubert, Pierre ;

Cremel, Gerard ;

Bennasroune, Amar .

FRONTIERS IN PHARMACOLOGY, 2015, 6

[7] Localised colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up [J].

Argiles, G. ;

Tabernero, J. ;

Labianca, R. ;

Hochhauser, D. ;

Salazar, R. ;

Iveson, T. ;

Laurent-Puig, P. ;

Quirke, P. ;

Yoshino, T. ;

Taieb, J. ;

Martinelli, E. ;

Arnold, D. .

ANNALS OF ONCOLOGY, 2020, 31 (10) :1291-1305

[8]

BAKER SJ, 1990, CANCER RES, V50, P7717

[9] Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial [J].

Bennouna, Jaafar ;

Sastre, Javier ;

Arnold, Dirk ;

Osterlund, Pia ;

Greil, Richard ;

Van Cutsem, Eric ;

von Moos, Roger ;

Maria Vieitez, Jose ;

Bouche, Olivier ;

Borg, Christophe ;

Steffens, Claus-Christoph ;

Alonso-Orduna, Vicente ;

Schlichting, Christoph ;

Reyes-Rivera, Irmarie ;

Bendahmane, Belguendouz ;

Andre, Thierry ;

Kubicka, Stefan .

LANCET ONCOLOGY, 2013, 14 (01) :29-37

[10] Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review [J].

Biller, Leah H. ;

Schrag, Deborah .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (07) :669-685

← 1 2 3 4 5 6 7 8 9 10 →