Fungal myosin-1 homologs as key molecular motors at the membrane-cytoskeleton interface

Class I myosin (myosin-1) is a small, single-headed myosin, distributing from lower eu-karyotes (such as fungi) to higher eukaryotes (such as vertebrates). Being able to interact with actin via the motor domain and to bind to membrane via the tail domain, myosin-1 plays a number of fundamental functions at the membrane-cytoskeleton interface. In fungi, myosin-1 is essential for many cellular processes, including endocytosis, hyphal growth, endoplasmic reticulum (ER) remodeling, and pathogenicity. In this review, we summarize the recent progress of fungal myosin-1 research in the past few years. We first introduce basic structure and function of each fungal myosin-1 domains, then compare the recently solved three-dimensional structure of fungal myosin-1 with that of vertebrate myosin-1, and finally focus on how fungal myosin-1 might participate in endocytosis and ER remodeling.(c) 2023 British Mycological Society. Published by Elsevier Ltd. All rights reserved.