Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia

被引：4

作者：

Cheon, Eun-jin ^{[1
,2
]}

Male, Alie G. ^{[1
]}

Gao, Bingchen ^{[1
]}

Adhikari, Bhim M. ^{[3
]}

Edmond, Jesse T. ^{[4
]}

Hare, Stephanie M. ^{[3
]}

Belger, Aysenil ^{[5
]}

Potkin, Steven G. ^{[6
]}

Bustillo, Juan R. ^{[7
]}

Mathalon, Daniel H. ^{[8
,9
]}

Ford, Judith M. ^{[8
,9
]}

Lim, Kelvin O. ^{[10
]}

Mueller, Bryon A. ^{[10
]}

Preda, Adrian ^{[6
]}

O'Leary, Daniel ^{[11
]}

Strauss, Gregory P. ^{[12
]}

Ahmed, Anthony O. ^{[13
]}

Thompson, Paul M. ^{[14
]}

Jahanshad, Neda

Kochunov, Peter ^{[3
]}

Calhoun, Vince D. ^{[4
]}

Turner, Jessica A. ^{[15
]}

van Erpa, Theo G. M. ^{[1
,16
,17
]}

机构：

[1] Univ Calif Irvine, Sch Med, Dept Psychiat & Human Behav, Clin Translat Neurosci Lab, Irvine, CA USA

[2] Yeungnam Univ Coll Med, Dept Psychiat, Daegu, South Korea

[3] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD USA

[4] Ctr Translat Res Neuroimaging & Data Sci TReNDS, GSU GATech Emory, Atlanta, GA USA

[5] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA

[6] Univ Calif Irvine, Sch Med, Dept Psychiat & Human Behav, Irvine, CA USA

[7] Univ New Mexico, Dept Psychiat & Neurosci, Albuquerque, NM USA

[8] Univ Calif San Francisco, Weill Inst Neurosci, Dept Psychiat, San Francisco, CA USA

[9] Vet Affairs San Francisco Healthcare Syst, San Francisco, CA USA

[10] Univ Minnesota, Dept Psychiat & Behav Sci, Minneapolis, MN USA

[11] Univ Iowa, Dept Psychiat, Iowa, IA USA

[12] Univ Georgia, Dept Psychol, Athens, GA USA

[13] Weill Cornell Med, Dept Psychiat, White Plains, NY USA

[14] Univ Southern Calif, Imaging Genet Ctr, Marina Del Rey, CA USA

[15] Ohio State Univ, Dept Psychiat, Columbus, OH USA

[16] Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA USA

[17] Univ Calif Irvine, Sch Med, Dept Psychiat & Human Behav, Clin & Translat Neurosci Lab, Irvine Hall,Room 109, Irvine, CA 92697 USA

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2023年 / 329卷

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

ALFF; Negative symptoms; Avolition; IMPACT;

D O I：

10.1016/j.pscychresns.2023.111597

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.

引用

页数：4

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