A Novel LncRNA MSTRG.310246.1 Promotes Differentiation and Thermogenesis in Goat Brown Adipocytes

被引：2
|
作者：
Tang, Jing [1 ,2 ]
Liu, Xin [1 ,2 ]
Su, Duo [1 ,2 ]
Jiang, Tingting [1 ,2 ]
Zhan, Siyuan [1 ,2 ]
Zhong, Tao [1 ,2 ]
Guo, Jiazhong [2 ]
Cao, Jiaxue [2 ]
Li, Li [1 ,2 ]
Zhang, Hongping [2 ]
Wang, Linjie [1 ,2 ]
机构：
[1] Sichuan Agr Univ, Coll Anim & Technol, Key Lab Livestock & Poultry Multi, Minist Agr & Rural Affairs, Chengdu 611130, Peoples R China
[2] Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key L, Chengdu 611130, Peoples R China
来源：
GENES | 2023年 / 14卷 / 04期
基金：
中国国家自然科学基金;
关键词：
lncRNA; thermogenesis; goat; brown adipocyte; brown adipose tissue; LONG NONCODING RNA; ADIPOSE-TISSUE; GENE; EVOLUTION;
D O I：
10.3390/genes14040833
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Brown adipose tissue (BAT) plays a critical role in maintaining the body temperature in newborn lamb due to its unique non-shivering thermogenesis. Previous studies have found that BAT thermogenesis is regulated by several long non-coding RNAs (lncRNAs). Here, we identified a novel lncRNA, MSTRG.310246.1, which was enriched in BAT. MSTRG.310246.1 was localized in both the nuclear and cytoplasmic compartments. In addition, MSTRG.310246.1 expression was upregulated during brown adipocyte differentiation. Overexpression of MSTRG.310246.1 increased the differentiation and thermogenesis of goat brown adipocytes. On the contrary, the knockdown of MSTRG.310246.1 inhibited the differentiation and thermogenesis of goat brown adipocytes. However, MSTRG.310246.1 had no effect on goat white adipocyte differentiation and thermogenesis. Our results show that MSTRG.310246.1 is a BAT-enriched LncRNA that improves the differentiation and thermogenesis of goat brown adipocytes.
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页数：12
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