High concentrations of fructose cause brain damage in mice

被引:0
作者
Cargnin-Carvalho, Anderson [1 ]
Silva, Mariella Reinol da [1 ]
Costa, Ana Beatriz [1 ]
Engel, Nicole Alessandra [1 ]
Farias, Bianca Xavier [1 ]
Bressan, Joice Benedet [1 ]
Backes, Kassiane Mathiola [1 ]
de Souza, Francielly [1 ]
da Rosa, Naiana [1 ]
de Oliveira Junior, Neri [1 ]
Goldim, Mariana Pereira de Souza [1 ]
Correa, Maria Eduarda Anastacio Borges [2 ]
Venturini, Ligia Milanez [2 ]
Fortunato, Jucelia Jeremias [1 ]
Prophiro, Josiane Somariva [3 ]
Petronilho, Fabricia [1 ]
Silveira, Paulo Cesar Lock [2 ]
Ferreira, Gabriela Kozuchovsk [4 ]
Rezin, Gislaine Tezza [1 ]
机构
[1] Univ Sul Santa Catarina, Lab Neurobiol Inflammatory & Metab Proc, Postgrad Program Hlth Sci, Florianopolis, SC, Brazil
[2] Univ Extremo Sul Catarinense, Postgrad Program Hlth Sci, Lab Expt Phisiopatol, Criciuma, SC, Brazil
[3] Univ Sul Santa Catarina, Postgrad Program Hlth Sci, Immunoparasitol Res Grp, Florianopolis, SC, Brazil
[4] Soc Educ Santa Catarina, Joinville, SC, Brazil
关键词
fructose; obesity; inflammation; oxidative damage; mitochondrial respiratory chain; INSULIN-RESISTANCE; HEPATIC STEATOSIS; RESPIRATORY-CHAIN; SKELETAL-MUSCLE; URIC-ACID; DIET; OBESITY; CONSUMPTION; DYSFUNCTION; GLUCOSE;
D O I
10.1139/bcb-2022-0088
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Excessive fructose consumption is associated with the incidence of obesity and systemic inflammation, resulting in increased oxidative damage and failure to the function of brain structures. Thus, we hypothesized that fructose consumption will significantly increase inflammation, oxidative damage, and mitochondrial dysfunction in the mouse brain and, consequently, memory damage. The effects of different fructose concentrations on inflammatory and biochemical parameters in the mouse brain were evaluated. Male Swiss mice were randomized into four groups: control, with exclusive water intake, 5%, 10%, and 20% fructose group. The 10% and 20% fructose groups showed an increase in epididymal fat, in addition to higher food consumption. Inflammatory markers were increased in epididymal fat and in some brain structures. In the evaluation of oxidative damage, it was possible to observe significant increases in the hypothalamus, prefrontal cortex, and hippocampus. In the epididymal fat and in the prefrontal cortex, there was a decrease in the activity of the mitochondrial respiratory chain complexes and an increase in the striatum. Furthermore, short memory was impaired in the 10% and 20% groups but not long memory. In conclusion, excess fructose consumption can cause fat accumulation, inflammation, oxidative damage, and mitochondrial dysfunction, which can damage brain structures and consequently memory.
引用
收藏
页码:313 / 325
页数:13
相关论文
共 50 条
[31]   Effect of various dietary fructose concentrations on the gallstone formation process in mice [J].
del Pozo, Reginald ;
Mardones, Lorena ;
Villagran, Marcelo ;
Munoz, Katia ;
Troncoso, Luciano ;
Mellado, Maximiliano ;
Munoz, Mirna .
NUTRICION HOSPITALARIA, 2024, 41 (01) :194-201
[32]   Supplementation of high doses of vitamin D during the gestational period do not cause reproductive, teratogenic and genotoxic damage in mice [J].
das Neves, Silvia Cordeiro ;
Auharek, Sarah Alves ;
Gomes, Roberto da Silva ;
Vilela, Marcelo Luiz Brandao ;
do Nascimento, Valter Aragao ;
Coelho, Henrique Rodrigues Scherer ;
Arunachalam, Karuppusamy ;
Antoniolli-Silva, Andreia Conceicao Milan Brochado ;
Oliveira, Rodrigo Juliano .
FOOD AND CHEMICAL TOXICOLOGY, 2024, 193
[33]   Physical Activity Offsets the Negative Effects of a High-Fructose Diet [J].
Bidwell, Amy J. ;
Fairchild, Timothy J. ;
Redmond, Jessica ;
Wang, Long ;
Keslacy, Stefan ;
Kanaley, Jill A. .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2014, 46 (11) :2091-2098
[34]   Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice [J].
Keskitalo, Anniina ;
Munukka, Eveliina ;
Toivonen, Raine ;
Hollmen, Maija ;
Kainulainen, Heikki ;
Huovinen, Pentti ;
Jalkanen, Sirpa ;
Pekkala, Satu .
PLOS ONE, 2018, 13 (05)
[35]   The Effect of Exercise Intensity on Pancreatic and Liver GLUT-2 Expression in High Fructose-Fed Mice [J].
Harianto, Tantia Dewi ;
Pamungkas, Bagas Trio ;
Rejeki, Purwo Sri ;
Wungu, Citrawati Dyah Kencono ;
Susanto, Joni ;
Izzatunnisa, Nabilah ;
Yuliawati, Tri Hartini ;
Halim, Shariff ;
Pranoto, Adi .
RETOS-NUEVAS TENDENCIAS EN EDUCACION FISICA DEPORTE Y RECREACION, 2024, (57) :35-47
[36]   Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to Fructose Consumption in Mice [J].
Ahn, In Sook ;
Lang, Jennifer M. ;
Olson, Christine A. ;
Diamante, Graciel ;
Zhang, Guanglin ;
Ying, Zhe ;
Byun, Hyae Ran ;
Cely, Ingrid ;
Ding, Jessica ;
Cohn, Peter ;
Kurtz, Ira ;
Gomez-Pinilla, Fernando ;
Lusis, Aldons J. ;
Hsiao, Elaine Y. ;
Yang, Xia .
JOURNAL OF NUTRITION, 2020, 150 (10) :2716-2728
[37]   Punicalagin Alleviates Oxidative Stress and Pathological Changes in Brain of Mice-Fed High Fat, High Fructose Diet [J].
Priya, Chandrasekaran Sathiya ;
Vidhya, Ramachandran ;
Jagan, Kalivarathan ;
Anuradha, Carani Venkatraman .
INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH, 2020, 10 (02) :L8-L17
[38]   High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease [J].
Spooner, Heather C. ;
Derrick, Stefani A. ;
Maj, Magdalena ;
Manjarin, Rodrigo ;
Hernandez, Gabriella V. ;
Tailor, Deepali S. ;
Bastani, Parisa S. ;
Fanter, Rob K. ;
Fiorotto, Marta L. ;
Burrin, Douglas G. ;
La Frano, Michael R. ;
Sikalidis, Angelos K. ;
Blank, Jason M. .
NUTRIENTS, 2021, 13 (12)
[39]   Maternal high-fat diet aggravates fructose-induced mitochondrial damage in skeletal muscles and causes differentiated adaptive responses on lipid metabolism in adult male offspring [J].
Woyames, Juliana ;
Pereira Souza, Aline Fonseca ;
Miranda, Rosiane Aparecida ;
Oliveira, Lorraine Soares ;
Caetano, Bruna ;
Vieira Andrade, Cherley Borba ;
Fortunato, Rodrigo Soares ;
Atella, Georgia Correa ;
Trevenzoli, Isis Hara ;
Souza, Luana Lopes ;
Pazos-Moura, Carmen Cabanelas .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2022, 104
[40]   LDT409 (pan-PPAR partial agonist) mitigates metabolic dysfunction-associated steatotic liver disease in high-fructose-fed mice [J].
Fernandes-da-Silva, Aline ;
Santana-Oliveira, Daiana Araujo ;
de Oliveira, Andressa S. ;
Ferreira, Thais A. M. ;
Monteiro, Natalia Cipriano ;
Silva-Veiga, Flavia Maria ;
Martins, Fabiane Ferreira ;
Cummins, Carolyn L. ;
Romeiro, Luiz Antonio Soares ;
Souza-Mello, Vanessa .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2024, 594