Dasatinib-induced follicular lymphoid hyperplasia, an entity to know

被引：0
作者：
Phelippeau, Mona [1 ]
Lefebvre, Christine [2 ]
Jacob, Marie-Christine [3 ]
Syrykh, Charlotte [4 ]
Ghelfi, Julien [5 ]
Carras, Sylvain [2 ,6 ,7 ]
Laurent, Camille [4 ]
Molina, Lysiane [7 ]
Valmary-Degano, Severine [1 ,6 ]
机构：
[1] CHU Grenoble Alpes, Serv Anat & Cytol Pathol, F-38000 Grenoble, France
[2] CHU Grenoble Alpes, Lab Hematol, F-38000 Grenoble, France
[3] CHU Grenoble Alpes, Lab Immunol, F-38000 Grenoble, France
[4] Inst Univ Canc Toulouse, Toulouse Oncopole, Serv Anat & Cytol pathol, F-31000 Toulouse, France
[5] CHU Grenoble Alpes, Dept Radiol, F-38000 Grenoble, France
[6] Univ Grenoble Alpes, Inst avancee Biosci IAB, Inserm U1209, CNRS UMR5309, F-38000 Grenoble, France
[7] Ctr Hosp Univ Grenoble Alpes, Serv dhematol, F-38000 Grenoble, France
来源：
ANNALES DE PATHOLOGIE | 2023年 / 43卷 / 01期
关键词：
Follicular lymphoid hyperplasia; Dasatinib; Side effects; Drug induced lymphadenopathy; TYROSINE KINASE INHIBITOR; LEUKEMIA;
D O I：
10.1016/j.annpat.2022.09.005
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Follicular lymphoid hyperplasia induced by dasatinib is an entity recently described. It is sometimes difficult to rule out the diagnostic of small B-cell lymphoma. Usually, the node is swollen, with follicular architecture conserved, composed by germinal centers with variable size and shape, with a hight number of mitoses and tingible bodies macrophages inside. Follicular lymphoid hyperplasia is isolated or associated with multiple reactive patterns. The immunohistochemical profil of germinal centers is CD20+, CD10+, BCL6+, BCL2-. Swollen node disappears in a short time after dasatinib discontinuation. Clinicians and pathologists need to be aware of this entity, so as not to avoid mistakenly suspect lymphoma when lymphadenopathy occurs in a patient with chronic myeloid leukemia treated with dasatinib. (c) 2022 Elsevier Masson SAS. All rights reserved.
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收藏
页码：45 / 51
页数：7
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