Biosynthesis of Melanin Nanoparticles for Photoacoustic Imaging Guided Photothermal Therapy

被引：27

作者：

Fu, Meijun ^{[1
,2
]}

Yang, Yuping ^{[3
]}

Zhang, Zhaomeng ^{[4
]}

He, Yaling ^{[1
]}

Wang, Yuanyuan ^{[4
]}

Liu, Chenxing ^{[1
]}

Xu, Xiaohong ^{[3
]}

Lin, Jing ^{[5
]}

Yan, Fei ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen Inst Synthet Biol, CAS Key Lab Quantitat Engn Biol, Shenzhen 518055, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Guangdong Med Univ, Affiliated Hosp, Dept Ultrasound, Zhanjiang 524001, Peoples R China

[4] Hebei Med Univ, Shijiazhuang 050011, Peoples R China

[5] Shenzhen Univ, Int Canc Ctr, Hlth Sci Ctr, Sch Biomed Engn,Marshall Lab Biomed Engn, Shenzhen 518060, Peoples R China

来源：

SMALL | 2023年 / 19卷 / 14期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

biosynthesis; melanin nanoparticles; photoacoustic imaging; photothermal therapy; PHOTODYNAMIC THERAPY; CARBON NANOTUBES; GENE; CLONING; AGENT;

D O I：

10.1002/smll.202205343

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photothermal therapy (PTT) has attracted considerable attention in recent years due to their unique advantages in minimal invasiveness and spatiotemporal selectivity. However, the fabrication procedures of PTT agents frequently require complex chemical and/or physical methods that involves harsh and environmentally hazardous conditions. Here, a genetically engineered bacterium is developed to synthesize melanin nanoparticles under mild and environmentally friendly conditions. The biosynthetic melanin nanoparticles exhibit excellent biocompatibility, good stability, and negligible toxicity. In addition, the biosynthetic melanin nanoparticles have strong absorption at near-infrared (NIR) region and higher photothermal conversion efficiency (48.9%) than chemically synthesized melanin-like polydopamine nanoparticles under an 808 nm laser irradiation. Moreover, the results show that the biosynthetic melanin nanoparticles have excellent photoacoustic imaging (PAI) performance and can be used for PAI guided PTT in vivo. In conclusion, the study provides an alternative approach to synthesize PTT agents with broad application potential in the diagnosis and treatment of cancer.

引用

页数：11

共 41 条

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