High resolution terahertz ATR frequency-domain spectroscopy for monitoring spinal cord injury in rats

被引：4

作者：

Fang, Xing ^{[1
]}

Huang, Hanxu ^{[2
]}

Zhang, Hongqi ^{[1
]}

Yang, Zuomin ^{[1
]}

Lyu, Zhidong ^{[1
]}

Yang, Hang ^{[1
]}

Li, Nan ^{[1
]}

Zhao, Tengfei ^{[2
]}

Yu, Xianbin ^{[1
]}

Zhang, Lu ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Informat Sci & Elect Engn, Hangzhou 310027, Peoples R China

[2] Zhejiang Univ, Dept Orthoped Surg, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Peoples R China

来源：

BIOMEDICAL OPTICS EXPRESS | 2024年 / 15卷 / 01期

基金：

中国国家自然科学基金;

关键词：

STATE;

D O I：

10.1364/BOE.507852

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Traumatic spinal cord injury (SCI) can lead to permanent neurological impairment, underscoring the urgency of regular therapeutic intervention and monitoring. In this study, we propose a new strategy for monitoring spinal cord injury through serum based on highresolution THz attenuated total reflection frequency domain spectroscopy (THz-ATR-FDS). We demonstrated serum spectral differences at different time points after experimental SCI in rats. We also studied the relationship between serum lipid concentration and the time of SCI, which revealed the potential of lipid molecules as biomarkers of SCI. In addition, based on the principal component analysis (PCA) and least squares regression (LSR) models, the quantitative relationship between the refractive index spectrum and lipid concentration in serum was automatically analyzed. This work highlights terahertz spectroscopy as a promising tool for label -free, periodic, and efficient monitoring of SCI.

引用

页码：479 / 490

页数：12

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