Diisoprenyl-cyclohexene-type meroterpenoids from a mangrove endophytic fungus Aspergillus sp. GXNU-Y65 and their anti-nonalcoholic steatohepatitis activity in AML12 cells

被引：8
作者：
Qin, Feng [1 ,3 ]
Luo, Li [1 ]
Liu, Yu-Chen [2 ]
Bo, Xiang-Long [1 ]
Wu, Fu-Rong [1 ]
Wang, Fan-Fan [3 ]
Tan, Mei-Jing [1 ]
Wei, You-Quan [1 ]
Dou, Xiao-Bing [2 ]
Wang, Cai Yi [2 ]
Huang, Xi-Shan [1 ]
Wang, Heng-Shan [1 ]
机构：
[1] Guangxi Normal Univ, Collaborat Innovat Ctr Guangxi Ethn Med, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resource,Key Lab, Guilin 541004, Peoples R China
[2] Zhejiang Chinese Med Univ, Coll Life Sci, Hangzhou 310053, Zhejiang, Peoples R China
[3] Yulin Normal Univ, Coll Chem & Food Sci, Guangxi Key Lab Agr Resources Chem & Biotechnol, Yulin 537000, Peoples R China
来源：
PHYTOCHEMISTRY | 2024年 / 218卷
关键词：
Aspergillus sp; Diisoprenyl-cyclohexene; Meroterpenoids; Aspergienynes a-I; Anti-nonalcoholic steatohepatitis activity;
D O I：
10.1016/j.phytochem.2023.113955
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nine previously undescribed diisoprenyl-cyclohexene-type meroterpenoids, aspergienynes A -I, together with five known analogues, were obtained from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y65. The diisoprenyl-cyclohexene-type meroterpenoids were elucidated based on multispectroscopic analysis, and the previously undescribed compounds' absolute configurations were established via electronic circular dichroism calculations. Biological activity results indicated that aspergienyne C (compound 3) had strong anti -nonalcoholic steatohepatitis activity against AML12 cells treated with PA (Palmitic acid) + OA (Oleic acid). At the same concentration of 20 mu M, 3 significantly reduced triglyceride (TG) content compared with fenofibrate (positive control) in PA + OA treated AML12 cells, and obviously increased phosphorylation of acetyl-CoA carboxylase.
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页数：10
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