Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice

被引：5

作者：

Oury, Cecile ^{[1
,2
,11
,12
]}

Meyers, Severien ^{[3
]}

Jacques, Nicolas ^{[1
,2
]}

Leeten, Kirsten ^{[1
,2
]}

Jiang, Zheshen ^{[1
,2
]}

Musumeci, Lucia ^{[1
,2
]}

Lox, Marleen ^{[3
]}

Debuisson, Margaux ^{[2
]}

Goffin, Eric ^{[4
]}

Pirotte, Bernard ^{[4
]}

Delvenne, Philippe ^{[5
,6
]}

Nchimi, Alain ^{[1
,2
]}

Hubert, Cedric ^{[7
]}

Heptia, Melanie ^{[7
]}

Hubert, Philippe ^{[7
]}

Kuijpers, Marijke J. E. ^{[8
]}

Vanassche, Thomas ^{[3
]}

Martinod, Kimberly ^{[3
]}

Verhamme, Peter ^{[3
]}

Lancellotti, Patrizio ^{[1
,2
,9
,10
]}

机构：

[1] Univ Liege Hosp, GIGA Inst, Ctr Hosp Univ CHU Liege, Lab Cardiol, Liege, Belgium

[2] Univ Liege Hosp, Ctr Hosp Univ CHU Liege, Dept Cardiol, Liege, Belgium

[3] Univ Leuven, Ctr Mol & Vasc Biol, Dept Cardiovasc Sci, Leuven, Belgium

[4] Univ Liege, Ctr Interdisciplinary Res Med CIRM, Ctr Hosp Univ, Lab Med Chem, Liege, Belgium

[5] Univ Liege, Ctr Hosp Univ Liege, Dept Pathol, Liege, Belgium

[6] Univ Liege, GIGA Inst, Lab Expt Pathol, Liege, Belgium

[7] Univ Liege, Lab Pharmaceut Analyt Chem, CIRM, Liege, Belgium

[8] Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Biochem, Maastricht, Netherlands

[9] Maria Cecilia Hosp Cotignola, Grp Villa Maria Care & Res, Bari, Italy

[10] Anthea Hosp, Bari, Italy

[11] Univ Liege Hosp, GIGA Inst, Ctr Hosp Univ CHU Liege, Lab Cardiol, Ave Hop 1,B34, B-4000 Liege, Belgium

[12] Univ Liege Hosp, Ctr Hosp Univ CHU Liege, Dept Cardiol, Ave Hop 1,B34, B-4000 Liege, Belgium

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2023年 / 8卷 / 11期

关键词：

bacterial virulence; infective endocarditis; Staphylococcus aureus; ticagrelor; CLUMPING FACTOR; PLUS ASPIRIN; MECHANISMS; THROMBOSIS; RISK;

D O I：

10.1016/j.jacbts.2023.02.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In addition to its potent antiplatelet activity, ticagrelor possesses antibacterial properties against gram-positive bacteria. We wondered whether the typical clinical dosage of ticagrelor could prevent the development of infective endocarditis caused by highly virulent Staphylococcus aureus. Ticagrelor prevented vegetation formation in a mouse model of inflammation-induced endocarditis. The dosage achieved in patients under ticagrelor therapy altered bacterial toxin production and adherence on activated endothelial cells, thereby mitigating bacterial virulence. Besides the previously described bactericidal activity at high doses, ticagrelor at typical clinical doses possesses antivirulence activity against S aureus. Ticagrelor antiplatelet activity further interferes with the interplay between platelets and bacteria.

引用

页码：1439 / 1453

页数：15

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