Poly-Agonist Pharmacotherapies for Metabolic Diseases: Hopes and New Challenges

被引：7
作者：
Allard, Camille [1 ]
Cota, Daniela [1 ]
Quarta, Carmelo [1 ]
机构：
[1] Univ Bordeaux, INSERM, Neuroctr Magendie, U1215, F-33000 Bordeaux, France
来源：
DRUGS | 2024年 / 84卷 / 02期
关键词：
GLUCAGON-LIKE PEPTIDE-1; GASTRIC-INHIBITORY POLYPEPTIDE; GLP-1 RECEPTOR AGONISTS; ADIPOSE-TISSUE THERMOGENESIS; ONCE-WEEKLY SEMAGLUTIDE; DIET-INDUCED OBESE; FOOD-INTAKE; WEIGHT-LOSS; BODY-WEIGHT; GLYCEMIC CONTROL;
D O I：
10.1007/s40265-023-01982-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The use of glucagon-like peptide-1 (GLP-1) receptor-based multi-agonists in the treatment of type 2 diabetes and obesity holds great promise for improving glycaemic control and weight management. Unimolecular dual and triple agonists targeting multiple gut hormone-related pathways are currently in clinical trials, with recent evidence supporting their efficacy. However, significant knowledge gaps remain regarding the biological mechanisms and potential adverse effects associated with these multi-target agents. The mechanisms underlying the therapeutic efficacy of GLP-1 receptor-based multi-agonists remain somewhat mysterious, and hidden threats may be associated with the use of gut hormone-based polyagonists. In this review, we provide a critical analysis of the benefits and risks associated with the use of these new drugs in the management of obesity and diabetes, while also exploring new potential applications of GLP-1-based pharmacology beyond the field of metabolic disease.
引用
收藏
页码：127 / 148
页数：22
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