Outcomes at 7 Years of Age of Former Very Preterm Neonates with Repeated Surfactant Treatment for Prolonged Respiratory Distress in the Neonatal Period

被引:0
作者
Hascoet, Jean-Michel [1 ,2 ]
Deforge, Helene [1 ,2 ]
Demoulin, Silvia [1 ,3 ]
Picaud, Jean-Charles [4 ]
Zupan, Veronique [5 ]
Ligi, Isabelle [6 ]
Moreau, Francois [7 ]
Labarre, Aurelie [8 ]
Daoud, Patrick [9 ]
Storme, Laurent [10 ]
Bonabel, Claude [3 ]
Hamon, Isabelle [1 ,2 ]
机构
[1] Lorraine Univ, DevAH Res Unit, F-54500 Vandoeuvre Les Nancy, France
[2] Ctr Hosp Reg Univ, Serv Medecine & Reanimat Neonatale, Matern Reg, F-54035 Nancy, France
[3] CHU, Serv Explorat Fonct Resp, F-54500 Vandoeuvre Les Nancy, France
[4] Hop Croix Rousse, Serv Neonatol & Reanimat Neonatale, Hosp Civils Lyon, F-69004 Lyon, France
[5] Hop Antoine Beclere, Serv Reanimat Neonatale, F-92141 Clamart, France
[6] Ctr Hosp Univ Concept, Serv Med & Reanimat Neonatale, F-13385 Marseille, France
[7] Ctr Hosp Univ Amiens Picardie, Serv Medecine Neonatale, Surveillance Continue & Reanimat Pediat Polyvalent, F-80000 Amiens, France
[8] Ctr Hosp Univ Charles Nicolle, Un Reanimat Pediat & Neonatale, F-76000 Rouen, France
[9] Ctr Hosp Intercommunal Gregoire, Dept Femmes Enfants, F-93100 Montreuil, France
[10] Ctr Hosp Reg Univ, Serv Medecine Neonatale, Sect Reanimat Neonatale, F-59037 Lille, France
关键词
extreme prematurity; surfactant; outcome; children; longitudinal study; pulmonary function testing; neurodevelopment; asthma; LOW-BIRTH-WEIGHT; QUALITY-OF-LIFE; LUNG INJURY; HEALTH; SURVIVORS; INFANTS; CHILDHOOD; CHILDREN; BORN; QUESTIONNAIRE;
D O I
10.3390/jcm12196220
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study aimed at evaluating the 7-year outcomes of 118 very preterm newborns (VPNs, gestational age = 26 +/- 1.4 w) involved in a randomized controlled trial. They presented neonatal respiratory distress (RDS), requiring ventilation for 14 +/- 2 days post-natal age (PNA). A repeated instillation of 200 mg/kg poractant alfa (SURF) did not improve early bronchopulmonary dysplasia, but the SURF infants needed less re-hospitalization than the controls for respiratory problems at 1- and 2-year PNA. There was no growth difference at 7.1 +/- 0.3 years between 41 SURF infants and 36 controls (80% of the eligible children), and 7.9% SURF infants vs. 28.6% controls presented asthma (p = 0.021). The children underwent cognitive assessment (WISC IV) and pulmonary function testing (PFT), measuring their spirometry, lung volume, and airway resistance. The spirometry measures showed differences (p < 0.05) between the SURF infants and the controls (mean +/- standard deviation (median z-score)) for FEV1 (L/s) (1.188 +/- 0.690(-0.803) vs. 1.080 +/- 0.243 (-1.446)); FEV1 after betamimetics (1.244 +/- 0.183(-0.525) vs. 1.091 +/- 0.20(-1.342)); FVC (L) (1.402 +/- 0.217 (-0.406) vs. 1.265 +/- 0.267 (-1.141)), and FVC after betamimetics (1.452 +/- 0.237 (-0.241) vs. 1.279 +/- 0.264 (-1.020)). PFT showed no differences in the volumes or airway resistance. The global IQ median (interquartile range) was 89 (82:99) vs. 89 (76:98), with 61% of the children >85 in both groups. Repeated surfactant treatment in VPNs presenting severe RDS led to the attenuation of early lung injuries, with an impact on long-term pulmonary sequelae, without differences in neurodevelopmental outcomes.
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页数:11
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