Study of the Effect of Nonselective Organic Solvent Nature on the Self-Organization of Amphiphilic Block Copolymers of D,L-Lactide and Ethylene Oxide in Aqueous Solution

被引：0
|
作者：
Kuznetsova, E. V. [1 ]
Shirokova, E. M. [1 ]
Puchkova, Yu. A. [1 ]
Yastremsky, E. V. [2 ]
Chvalun, S. N. [1 ,3 ]
机构：
[1] Natl Res Ctr Kurchatov Inst, Moscow 123182, Russia
[2] Russian Acad Sci, Fed Res Ctr Crystallog & Photon, Moscow 119333, Russia
[3] Russian Acad Sci, Enikolopov Inst Synthet Polymer Mat, Moscow 117393, Russia
来源：
POLYMER SCIENCE SERIES C | 2023年 / 65卷 / 01期
关键词：
NANOPARTICLES; POLYMER; MICELLES; PLA;
D O I：
10.1134/S1811238223700352
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The self- organization of biocompatible amphiphilic block copolymers of D,L-lactide and ethylene oxide with various hydrophobic poly(D,L-lactide) block length in aqueous media has been investigated. It has been shown that the nature of nonselective organic solvent has a considerable effect on the size, size polydispersity, and morphology of micelles of a block copolymer with a long poly(D,L-lactide) block. To elucidate the dependence of properties of block copolymer micelles on the common organic solvent type (acetone, tetrahydrofuran, N,N-dimethylformamide, and acetonitrile) various parameters of the used solvents have been estimated, and correlation between the Flory-Huggins coefficient and the surface tension between the hydrophobic block and the nonselective organic solvent and the parameters of micellar structures has been found.
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页码：128 / 142
页数：15
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