SARS-CoV-2 Hybrid Immunity: The Best of Both Worlds

被引：43

作者：

Lasrado, Ninaad ^{[1
]}

Barouch, Dan H. ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, 330 Brookline Ave,E CLS-1043, Boston, MA 02115 USA

[2] Ragon Inst Massachusetts Gen Hosp Massachusetts In, Cambridge, MA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2023年 / 228卷 / 10期

关键词：

SARS-CoV-2; hybrid immunity; mRNA vaccines; COVID-19; T cells; neutralizing antibodies;

D O I：

10.1093/infdis/jiad353

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three and a half years into the coronavirus disease 2019 (COVID-19) pandemic, the nature and durability of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) still remains unclear. Current COVID-19 mRNA vaccines have been shown to provide minimal protection against infection with XBB variants but substantial protection against severe disease. However, such protection appears to wane quickly. In contrast, protection from the combination of both vaccination and infection, termed "hybrid immunity", has been shown to be greater in magnitude and durability than that provided by either vaccine immunity or natural immunity alone.

引用

页码：1311 / 1313

页数：3

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