Effects of Bacillus Calmette-Guerin on immunometabolism, microbiome and liver diseases

被引:2
作者
Ijaz, Muhammad Umair [1 ]
Vaziri, Farzam [1 ]
Wan, Yu-Jui Yvonne [1 ]
机构
[1] Univ Calif Davis, Sch Med, Dept Med Pathol & Lab Med, Sacramento, CA 95817 USA
基金
美国国家卫生研究院;
关键词
Bacillus Calmette-Guerin (BCG); Liver disease; Vaccination; Gut microbiota; Metabolic diseases; Trained immunity; Diabetes; TRAINED INNATE IMMUNITY; METABOLIC SYNDROME; BCG VACCINE; CHOLESTEROL; INFLAMMATION; INFECTION; CELLS; MACROPHAGES; PROGRESSION; GLYCOLYSIS;
D O I
10.1016/j.livres.2023.05.001
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Metabolic diseases have overtaken infectious diseases as the most serious public health issue and economic burden in most countries. Moreover, metabolic diseases increase the risk of having infectious diseases. The treatment of metabolic disease may require a long-term strategy of taking multiple medications, which can be costly and have side effects. Attempts to expand the therapeutic use of vaccination to prevent or treat metabolic diseases have attracted significant interest. A growing body of evidence indicates that Bacillus Calmette-Guerin (BCG) offers protection against non-infectious diseases. The non-specific effects of BCG occur likely due to the induction of trained immunity. In this regard, understanding how BCG influences the development of chronic metabolic health including liver diseases would be important. This review focuses on research on BCG, the constellation of disorders associated with metabolic health issues including liver diseases and diabetes as well as how BCG affects the gut microbiome, immunity, and metabolism. (c) 2023 The Third Affiliated Hospital of Sun Yat-sen University. Publishing services by Elsevier B. V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:116 / 123
页数:8
相关论文
共 95 条
[41]   Whole-genome sequencing of East Asian lung cancers reveals new germline pathogenic variants [J].
Mukherjee, Semanti ;
Carrot-Zhang, Jian .
CANCER CELL, 2022, 40 (10) :1081-1083
[42]   Type 1 diabetes mellitus [J].
Katsarou, Anastasia ;
Gudbjornsdottir, Soffia ;
Rawshani, Araz ;
Dabelea, Dana ;
Bonifacio, Ezio ;
Anderson, Barbara J. ;
Jacobsen, Laura M. ;
Schatz, Desmond A. ;
Lernmark, Ake .
NATURE REVIEWS DISEASE PRIMERS, 2017, 3
[43]   M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity [J].
Khan, Nargis ;
Downey, Jeffrey ;
Sanz, Joaquin ;
Kaufmann, Eva ;
Blankenhaus, Birte ;
Pacis, Alain ;
Pernet, Erwan ;
Ahmed, Eisha ;
Cardoso, Silvia ;
Nijnik, Anastasia ;
Mazer, Bruce ;
Sassetti, Christopher ;
Behr, Marcel A. ;
Soares, Miguel P. ;
Barreiro, Luis B. ;
Divangahi, Maziar .
CELL, 2020, 183 (03) :752-+
[44]   Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes [J].
Kleinnijenhuis, Johanneke ;
Quintin, Jessica ;
Preijers, Frank ;
Joosten, Leo A. B. ;
Ifrim, Daniela C. ;
Saeed, Sadia ;
Jacobs, Cor ;
van Loenhout, Joke ;
de Jong, Dirk ;
Stunnenberg, Hendrik G. ;
Xavier, Ramnik J. ;
van der Meer, Jos W. M. ;
van Crevel, Reinout ;
Netea, Mihai G. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (43) :17537-17542
[45]   Islet regeneration during the reversal of autoimmune diabetes in NOD mice [J].
Kodama, S ;
Kühtreiber, W ;
Fujimura, S ;
Dale, EA ;
Faustman, DL .
SCIENCE, 2003, 302 (5648) :1223-1227
[46]   BCG vaccination in humans inhibits systemic inflammation in a sex-dependent manner [J].
Koeken, Valerie A. C. M. ;
de Bree, L. Charlotte J. ;
Mourits, Vera P. ;
Moorlag, Simone J. C. F. M. ;
Walk, Jona ;
Cirovic, Branko ;
Arts, Rob J. W. ;
Jaeger, Martin ;
Dijkstra, Helga ;
Lemmers, Heidi ;
Joosten, Leo A. B. ;
Benn, Christine S. ;
van Crevel, Reinout ;
Netea, Mihai G. .
JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (10) :5591-5602
[47]   BCG and protection against inflammatory and auto-immune diseases [J].
Kowalewicz-Kulbat, Magdalena ;
Locht, Camille .
EXPERT REVIEW OF VACCINES, 2017, 16 (07) :699-708
[48]   BCG Vaccinations Upregulate Myc, a Central Switch for Improved Glucose Metabolism in Diabetes [J].
Kuhtreiber, Willem M. ;
Takahashi, Hiroyuki ;
Keefe, Ryan C. ;
Song, Yaerin ;
Tran, Lisa ;
Luck, Trevor G. ;
Shpilsky, Gabriella ;
Moore, Louisa ;
Sinton, Sarah M. ;
Graham, Jessica C. ;
Faustman, Denise L. .
ISCIENCE, 2020, 23 (05)
[49]   BCG Therapy for Type 1 Diabetes: Restoration of Balanced Immunity and Metabolism [J].
Kuhtreiber, Willem M. ;
Faustman, Denise L. .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2019, 30 (02) :80-92
[50]   Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations [J].
Kuhtreiber, Willem M. ;
Tran, Lisa ;
Kim, Taesoo ;
Dybala, Michael ;
Nguyen, Brian ;
Plager, Sara ;
Huang, Daniel ;
Janes, Sophie ;
Defusco, Audrey ;
Baum, Danielle ;
Zheng, Hui ;
Faustman, Denise L. .
NPJ VACCINES, 2018, 3