Effects of Bacillus Calmette-Guerin on immunometabolism, microbiome and liver diseases

被引：2
作者：
Ijaz, Muhammad Umair [1 ]
Vaziri, Farzam [1 ]
Wan, Yu-Jui Yvonne [1 ]
机构：
[1] Univ Calif Davis, Sch Med, Dept Med Pathol & Lab Med, Sacramento, CA 95817 USA
来源：
LIVER RESEARCH | 2023年 / 7卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Bacillus Calmette-Guerin (BCG); Liver disease; Vaccination; Gut microbiota; Metabolic diseases; Trained immunity; Diabetes; TRAINED INNATE IMMUNITY; METABOLIC SYNDROME; BCG VACCINE; CHOLESTEROL; INFLAMMATION; INFECTION; CELLS; MACROPHAGES; PROGRESSION; GLYCOLYSIS;
D O I：
10.1016/j.livres.2023.05.001
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Metabolic diseases have overtaken infectious diseases as the most serious public health issue and economic burden in most countries. Moreover, metabolic diseases increase the risk of having infectious diseases. The treatment of metabolic disease may require a long-term strategy of taking multiple medications, which can be costly and have side effects. Attempts to expand the therapeutic use of vaccination to prevent or treat metabolic diseases have attracted significant interest. A growing body of evidence indicates that Bacillus Calmette-Guerin (BCG) offers protection against non-infectious diseases. The non-specific effects of BCG occur likely due to the induction of trained immunity. In this regard, understanding how BCG influences the development of chronic metabolic health including liver diseases would be important. This review focuses on research on BCG, the constellation of disorders associated with metabolic health issues including liver diseases and diabetes as well as how BCG affects the gut microbiome, immunity, and metabolism. (c) 2023 The Third Affiliated Hospital of Sun Yat-sen University. Publishing services by Elsevier B. V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码：116 / 123
页数：8
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