Immune homeostasis modulation by hydrogel-guided delivery systems: a tool for accelerated bone regeneration

被引：10

作者：

Mi, Bobin ^{[1
,2
]}

Xiong, Yuan ^{[1
,2
]}

Zha, Kangkang ^{[1
,2
]}

Cao, Faqi ^{[1
,2
]}

Zhou, Wu ^{[1
,2
]}

Abbaszadeh, Samin ^{[3
]}

Ouyang, Lizhi ^{[1
,2
]}

Liao, Yuheng ^{[1
,2
]}

Hu, Weixian ^{[1
,2
]}

Dai, Guandong ^{[4
]}

Zhao, Zhiming ^{[5
]}

Feng, Qian ^{[6
]}

Shahbazi, Mohammad-Ali ^{[3
,7
]}

Liu, Guohui ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Orthoped, 1277 Jiefang Ave, Wuhan 430022, Peoples R China

[2] Hubei Prov Key Lab Oral & Maxillofacial Dev & Rege, Wuhan 430022, Peoples R China

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Engn, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands

[4] Southern Med Univ, Pingshan Dist Peoples Hosp Shenzhen, Pingshan Gen Hosp, Dept Orthoped Surg, Shenzhen 518118, Peoples R China

[5] Hubei Univ Med, Suizhou Hosp, Dept Orthoped, Suizhou 441300, Peoples R China

[6] Chongqing Univ, Coll Bioengn, Minist Educ, Key Lab Biorheol Sci & Technol, Chongqing 400044, Peoples R China

[7] Univ Groningen, WJ Kolff Inst Biomed Engn & Mat Sci, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands

来源：

BIOMATERIALS SCIENCE | 2023年 / 11卷 / 18期

基金：

中国博士后科学基金; 美国国家科学基金会;

关键词：

MESENCHYMAL STEM-CELLS; HYALURONIC-ACID; T-CELLS; ENDOTHELIAL-CELLS; MACROPHAGES; RELEASE; INJURY; REPAIR; MICE; OSTEOIMMUNOLOGY;

D O I：

10.1039/d3bm00544e

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Immune homeostasis is delicately mediated by the dynamic balance between effector immune cells and regulatory immune cells. Local deviations from immune homeostasis in the microenvironment of bone fractures, caused by an increased ratio of effector to regulatory cues, can lead to excessive inflammatory conditions and hinder bone regeneration. Therefore, achieving effective and localized immunomodulation of bone fractures is crucial for successful bone regeneration. Recent research has focused on developing localized and specific immunomodulatory strategies using local hydrogel-based delivery systems. In this review, we aim to emphasize the significant role of immune homeostasis in bone regeneration, explore local hydrogel-based delivery systems, discuss emerging trends in immunomodulation for enhancing bone regeneration, and address the limitations of current delivery strategies along with the challenges of clinical translation.

引用

页码：6035 / 6059

页数：25

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