From patterns to patients: Advances in clinical machine learning for cancer diagnosis, prognosis, and treatment

Machine learning (ML) is increasingly used in clinical oncology to diagnose cancers, predict patient out-comes, and inform treatment planning. Here, we review recent applications of ML across the clinical oncology workflow. We review how these techniques are applied to medical imaging and to molecular data obtained from liquid and solid tumor biopsies for cancer diagnosis, prognosis, and treatment design. We discuss key considerations in developing ML for the distinct challenges posed by imaging and molecular data. Finally, we examine ML models approved for cancer-related patient usage by regulatory agencies and discuss approaches to improve the clinical usefulness of ML.