Effect of ten different biomarkers in the gingival crevicular fluid of obese and non-obese undergoing fixed orthodontic treatment

被引：0

作者：

Alqerban, A. ^{[1
]}

Asiri, S. N. ^{[1
]}

Alharbi, F. ^{[1
]}

Almalki, A. ^{[3
]}

Alqhtani, N. ^{[2
]}

Alenazi, A. ^{[2
]}

Robaian, A. ^{[4
]}

Samran, A. ^{[5
]}

机构：

[1] Prince Sattam bin Abdulaziz Univ, Dept Prevent Dent Sci, Al Kharj, Saudi Arabia

[2] Prince Sattam bin Abdulaziz Univ, Coll Dent, Dept Oral & Maxillofacial Surg & Diagnost Sci, Al Kharj, Saudi Arabia

[3] Majmaah Univ, Coll Dent, Dept Prevent Dent Sci Orthodont, Al Majmaah 11942, Saudi Arabia

[4] Prince Sattam bin Abdulaziz Univ, Coll Dent, Dept Conservat Dent Sci, Al Kharj, Saudi Arabia

[5] Dar Al Uloom Univ, Coll Dent, Dept Restorat & Prosthet Dent Sci, Riyadh 11942, Saudi Arabia

来源：

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2023年 / 27卷 / 05期

关键词：

Gingival crevicular fluid; Obese; Non-obese; Fixed orthodontic appliance; Biomarkers; SALIVARY LEPTIN; NORMAL-WEIGHT; INFLAMMATION; OVERWEIGHT; SURGERY; TISSUE; RISK;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

OBJECTIVE: The aim of this study is to evaluate the effect of ten proinflam-matory cytokines in GCF of participants with raised body mass index (BMI) compared to non -obese subjects undergoing fixed orthodontic treatment.PATIENTS AND METHODS: In the cross-sec-tional cohort, subjects were shortlisted through the purposive sampling method with the same age and gender and similar characteristics (co-hort). For inclusion and exclusion, predefined criteria were followed. In all included partici-pants obese and non-obese collection of GCF was made from mandibular canine to canine. Identification of inflammatory mediators (MPO and CRP) leptin, adiponectin, and resistin (pg/ mL). Bone remodeling biomarkers RANKL (pg/ mL) and tissue remodeling biomarkers MMP8, MMP9, TIMP1, and MMP8/TIMP1, MMP9/TIMP1 ratio were collected and blinded by the investi-gator. Normal distribution of data i.e., age, BMI, the flow rate of GCF, indices plaque and gingi-val, and uWMS were compared using a t-test. Non-normality biomarker data were evaluated using Mann-Whitney U-test. To assess the rela-tionship between the concentration of GCF bio-markers and plaque and gingival indices Pear-son and Spearman correlation coefficients were used.RESULTS: The total number of participants included was 44. In the obese and non-obese groups, the male/female ratio was the same i.e., (n=11 each). The mean age of participants in the obese group was 25.7 +/- 1.55 years, whereas the non-obese group was 26.1 +/- 1.29 years. In obese the mean BMI was 33.6 +/- 2.1 kg/m2 whereas in non-obese 22.9 +/- 1.9 kg/m2 (p<0.02). Among the levels of biomarkers adiponectin (p<0.006) and leptin (p<0.028) demonstrated a significant dif-ference between obese and non-obese partici-pants. Also, a significant difference was noted between obese and non-obese in tissue remod-eling biomarker MMP9 (p<0.03).CONCLUSIONS: A surge in the level of the biomarkers, i.e., MMP9, leptin, and adiponectin in the gingival crevicular fluid is found in obese undergoing fixed orthodontic treatment.

引用

页码：1722 / 1728

页数：7