CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma

被引：9

作者：

Shen, Yuehong ^{[1
,2
,3
,4
,5
,6
]}

Chen, Yuling ^{[1
,2
,3
,4
]}

Lin, Yuntao ^{[1
,2
,3
,4
]}

Li, Yicun ^{[1
,2
,3
,4
]}

Liu, Pengfei ^{[5
,6
]}

Zhang, Biru ^{[1
,2
,3
,4
,7
]}

Wang, Yufan ^{[1
,2
,3
,4
]}

Chan, King-Chi ^{[8
]}

Mak, Nai-Ki ^{[9
]}

Kahn, Michael ^{[10
]}

Qi, Robert Z. Z. ^{[5
,11
]}

Yang, Hongyu ^{[1
,2
,3
,4
,6
]}

机构：

[1] Peking Univ, Shenzhen Hosp, Stomatol Ctr, Dept Oral & Maxillofacial Surg, Shenzhen, Peoples R China

[2] Guangdong Prov High Level Clin Key Specialty, Guangzhou, Peoples R China

[3] Guangdong Prov Engn Res Ctr Oral Dis Diag & Treatm, Guangzhou, Peoples R China

[4] Hong Kong Univ Sci & Technol, Peking Univ, Shenzhen Peking Univ, Shenzhen Hosp,Med Ctr,Inst Stomatol, Guangzhou, Guangdong, Peoples R China

[5] Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Peoples R China

[6] Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Hong Kong, Peoples R China

[7] Shenzhen Luohu Peoples Hosp, Dept Stomatol, Shenzhen, Guangdong, Peoples R China

[8] Univ Hong Kong, Ctr PanorOm Sci, Hong Kong, Peoples R China

[9] Hong Kong Baptist Univ, Dept Biol, Hong Kong, Peoples R China

[10] City Hope Natl Med Ctr, Beckman Res Inst, Dept Mol Med, Duarte, CA USA

[11] Hong Kong Univ Sci & Technol Guangzhou, Biosci & Biomed Engn Thrust, Syst Hub, Guangzhou, Guangdong, Peoples R China

来源：

CELL DEATH & DISEASE | 2023年 / 14卷 / 02期

基金：

中国国家自然科学基金;

关键词：

CANCER; HEAD; GROWTH; DIFFERENTIATION; EXPRESSION; CATENIN; PROTEIN; MARKER; IDENTIFICATION; INHIBITOR;

D O I：

10.1038/s41419-023-05652-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In oral squamous cell carcinoma (OSCC), a highly aggressive and frequently lethal malignancy, the role and action mechanism of the microtubule regulatory protein CDK5RAP2 have not been fully understood. Here, we show that CDK5RAP2 is highly expressed in OSCC and its expression correlates with clinical stage and lymph node metastasis of the disease. The expression of CDK5RAP2 is regulated by the Wnt signaling pathway. Depletion of CDK5RAP2 inhibits the tumorigenesis and migration of OSCC cells and alters the OSCC cancer stem (-like) cell (CSC) signature. Notably, suppression of CDK5RAP2 expression disrupts spindle orientation during mitosis. Collectively, these results identify CDK5RAP2 as a potential CSC marker and reveal a mechanism that controls the CSC population in OSCC.

引用

页数：11

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