Profiling of Antibiotic Residues in Surface Water of River Yamuna Stretch Passing through Delhi, India

The River Yamuna is one of the largest rivers in northern India. It serves as a major source of potable water to the National Capital Delhi. A study was carried out to monitor and quantify three common antibiotics in surface water, with the help of Ultra-Performance Liquid Chromatography (UPLC) coupled with the Mass spectrophotometer (MS/MS)-based method. All the major river water locations in the research area were sampled in triplicate to determine the significant presence of antibiotics from local areas, hospitals, drug manufacturing facilities, and residential areas. Using spiked, as well as actual samples, an optimized method for the detection and quantification of different concentrations of antibiotics was developed. Spatiotemporal variations in the physicochemical properties at the five sites, including reference site-6 (Jamia Millia Islamia), during the pre-monsoon and post-monsoon period, were also investigated. Maximum concentration was observed during the pre-monsoon season followed by the post-monsoon season. The highest detected antibiotic concentration from the river water samples was that of ofloxacin (145.3794 ng/mL), followed by amoxicillin (3.033 ng/mL) and erythromycin (2.171 ng/mL). An aquatic environment may be very vulnerable to dangers from these pharmaceutical residues, according to this risk assessment. Additionally, the levels and compositions of pharmaceutical residue in the aquatic ecosystem might be influenced by seasonal agricultural application, precipitation, and temperature. The findings revealed the existence of antibiotics because of their indiscriminate usage, which may have resulted in the development of resistant strains and ultimately contributed to the spread of antibiotic resistance among living organisms in the river. Thus, attention is required particularly to this section of river as it is the local lifeline source for urban consumers for the domestic water supply and farmers for cultivation.