RIOK2 Contributes to Cell Growth and Protein Synthesis in Human Oral Squamous Cell Carcinoma

被引：2
|
作者：
Matsuzaki, Yusuke [1 ,2 ]
Naito, Yutaka [1 ]
Miura, Nami [1 ]
Mori, Taisuke [3 ]
Watabe, Yukio [4 ]
Yoshimoto, Seiichi [5 ]
Shibahara, Takahiko [2 ]
Takano, Masayuki [2 ]
Honda, Kazufumi [1 ,6 ]
机构：
[1] Nippon Med Sch, Inst Adv Med Sci, Dept Bioregulat, Tokyo 1138602, Japan
[2] Tokyo Dent Coll, Dept Oral & Maxillofacial Surg, Tokyo 1010061, Japan
[3] Natl Canc Ctr, Dept Diagnost Pathol, Tokyo 1040045, Japan
[4] Tokyo Metropolitan Tama Med Ctr, Dept Dent & Oral Surg, Tokyo 1838524, Japan
[5] Natl Canc Ctr, Dept Head & Neck Surg, Tokyo 1040045, Japan
[6] Nippon Med Sch, Grad Sch Med, Dept Bioregulat, Tokyo 1138602, Japan
来源：
CURRENT ONCOLOGY | 2023年 / 30卷 / 01期
关键词：
RIOK2; biomarker; tongue squamous cell carcinoma; ribosome; protein synthesis; RIBOSOME BIOGENESIS; CANCER;
D O I：
10.3390/curroncol30010031
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ribosomes are responsible for the protein synthesis that maintains cellular homeostasis and is required for the rapid cellular division of cancer cells. However, the role of ribosome biogenesis mediators in the malignant behavior of tongue squamous cell carcinoma (TSCC) is unknown. In this study, we found that the expression of RIOK2, a key enzyme involved in the maturation steps of the pre-40S ribosomal complex, was significantly associated with poorer overall survival in patients with TSCC. Further, multivariate analysis revealed that RIOK2 is an independent prognostic factor (hazard ratio, 3.53; 95% confidence interval, 1.19-10.91). Inhibition of RIOK2 expression by siRNA decreased cell growth and S6 ribosomal protein expression in oral squamous cell carcinoma cell lines. RIOK2 knockdown also led to a significant decrease in the protein synthesis in cancer cells. RIOK2 has potential application as a novel therapeutic target for TSCC treatment.
引用
收藏
页码：381 / 391
页数：11
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