Determination of distribution coefficients of mercury and gold on selected extraction chromatographic resins-towards an improved separation method of mercury-197 from proton-irradiated gold targets

被引：8
作者：
Chen, Shaohuang [1 ,2 ]
Bas, Marine [3 ]
Happel, Steffen [3 ]
Randhawa, Parmissa [1 ,2 ]
McNeil, Scott [1 ]
Kurakina, Elena [1 ]
Zeisler, Stefan [1 ]
Maskell, Keiran [1 ,2 ]
Hoehr, Cornelia [1 ,4 ,5 ]
Ramogida, Caterina F. [1 ,2 ]
Radchenko, Valery [1 ,6 ]
机构：
[1] TRIUMF, Life Sci Div, 4004 Wesbrook Mall, Vancouver, BC V6T 2A3, Canada
[2] Simon Fraser Univ, Dept Chem, 8888 Univ Dr, Burnaby, BC V5A 1S6, Canada
[3] TrisKem Int SAS, 3 Rue Champs Geons ZAC Eperon, F-35170 Bruz, Brittany, France
[4] Univ Victoria, Dept Phys & Astron, 3800 Finnerty Rd, Victoria, BC V8P 5C2, Canada
[5] Univ British Columbia Okanagan, Dept Comp Sci Math Phys & Stat, 3187 Univ Way, Kelowna, BC V1V 1V7, Canada
[6] Univ British Columbia, Dept Chem, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada
来源：
JOURNAL OF CHROMATOGRAPHY A | 2023年 / 1688卷
基金：
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词：
Mercury-197; Gold; Proton irradiation; Distribution coefficient; Extraction chromatography; RADIOIMMUNOTHERAPY; THERAPY; I-125; DECAY; DNA;
D O I：
10.1016/j.chroma.2022.463717
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Radioisotope mercury-197g (197gHg, half-life: 64.14 h) along with its metastable isomer (197mHg, half-life: 23.8 h) are potential candidates for targeted Meitner-Auger electron therapy due to their suitable decay properties. Their production can be achieved via proton irradiation of a natural gold target, but the num-ber of studies surrounding their separation from an irradiated gold target is limited. This study focuses on the determination of distribution coefficients (Kd) of gold (III) and mercury (II) on seven extraction chro-matographic resins. Mercury Kd were measured by means of radiotracers and Inductively Coupled Plasma Mass Spectrometry (ICP_MS); values obtained from the two methods were generally in good agreement. These results can provide insight on Hg and Au chemistry and aid in the design of improved separation system(s). (c) 2022 Elsevier B.V. All rights reserved.
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页数：11
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