Insights into elastic fiber fragmentation: Mechanisms and treatment of aortic aneurysm in Marfan syndrome

被引:6
|
作者
Seeburun, Sheilabi [1 ,4 ,5 ]
Wu, Shichao [1 ]
Hemani, Darshi [2 ]
Pham, Lucynda [1 ,2 ]
Ju, Donghong [1 ,3 ]
Xie, Youming [3 ]
Kata, Priyaranjan [1 ]
Li, Li [1 ,2 ,4 ]
机构
[1] Wayne State Univ, Dept Internal Med, Detroit, MI USA
[2] Wayne State Univ, Ctr Mol Med & Genet, Detroit, MI USA
[3] Wayne State Univ, Dept Oncol, Detroit, MI USA
[4] 421 E Canfield Ave,Room 2146, Detroit, MI 48201 USA
[5] Rutgers Hlth Community Med Ctr, Dept Internal Med, Toms River, NJ USA
关键词
Elastic fiber fragmentation; Marfan syndrome; Fibrillin-1; Aortic aneurysm; MMP; TGF-beta; Elastin; Losartan; Angiotensin receptor blocker (ARB); SMOOTH-MUSCLE-CELLS; TGF-BETA; MOUSE MODEL; FIBRILLIN; BINDING; PATHOGENESIS; EXPRESSION; LOSARTAN; MICROFIBRILS; PROGRESSION;
D O I
10.1016/j.vph.2023.107215
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutations in fibrillin 1 (FBN1) gene. These mutations result in defects in the skeletal, ocular, and cardiovascular systems. Aortic aneurysm is the leading cause of premature mortality in untreated MFS patients. Elastic fiber fragmentation in the aortic vessel wall is a hallmark of MFS-associated aortic aneurysms. FBN1 mutations result in FBN1 fragments that also contribute to elastic fiber fragmentation. Although recent research has advanced our understanding of MFS, the contribution of elastic fiber fragmentation to the pathogenesis of aneurysm formation remains poorly understood. This review provides a comprehensive overview of the molecular mechanisms of elastic fiber fragmentation and its role in the pathogenesis of aortic aneurysm progression. Increased comprehension of elastic fragmentation has significant clinical implications for developing targeted interventions to block aneurysm progression, which would benefit not only individuals with Marfan syndrome but also other patients with aneurysms. Moreover, this review highlights an overlooked connection between inhibiting aneurysm and the restoration of elastic fibers in the vessel wall with various aneurysm inhibitors, including drugs and chemicals. Investigating the underlying molecular mechanisms could uncover innovative therapeutic strategies to inhibit elastin fragmentation and prevent the progression of aneurysms.
引用
收藏
页数:8
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