Perceptions into causes and consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants

被引:0
作者
Laxminarayana, Dama [1 ]
机构
[1] Sathya Krishna Genom LLC, Winston Salem, NC USA
来源
RHEUMATOLOGY & AUTOIMMUNITY | 2023年 / 3卷 / 01期
关键词
gene regulation; innate immunity; mutations; RNA editing enzymes; SARS-CoV-2; pathogenesis; type I interferons; MOLECULAR-BASIS; RNA; EXCISION;
D O I
10.1002/rai2.12065
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are emerging worldwide and pathogenicity varies widely from no symptoms to death. The SARS-CoV-2 is evolving as lineages like Alpha, Beta, Gamma, Epsilon, Iota, Delta, and Omicron in the course of time. The main reasons for such viral evolution are (a) the imperfect nature of SARS-CoV-2 RNA polymerase, and viral exonuclease mediated proofreading functions resulting in the generation of mutations in viral genomes; (b) fusions of the 5 leader sequence to unexpected 3 sites, and transcription regulatory sequences (TRSs) in subgenomic RNAs (sgRNAs), which result in the generation of structural variants and novel open reading frames; (c) these viruses are combated by the host type I interferons (IFNs). In such a process IFNs upregulate viral RNA editing APOBEC3G/F and ADAR1 genes, which induce mutations in viral genomes. These factors play important roles in causing viral evolution and the emergence of more efficient SARS-CoV-2 genomes, which escape the host immune defense system, and vaccine-elicited antibodies and impede therapeutic strategies. The main challenges we now face are how to control future SARS-CoV-2 evolution, the elimination of their deleterious side effects, and the onset of new diseases as aftermaths of SARS-CoV-2 infections. Preventive measures like (a) the development of broadly neutralizing antibodies and novel vaccines, therapies based on genomics and proteomics data will help in avoiding, and/or minimizing SARS-CoV-2 infections; (b) targeted therapies, application of patient-based precision medicine methodology can help in achieving the goal and avoiding unwanted deleterious side effects and the onset of SARS-CoV-2 infections mediated several diseases in future.
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页码:1 / 8
页数:8
相关论文
共 65 条
[1]   Dysregulation of type I interferon responses in COVID-19 [J].
Acharya, Dhiraj ;
Liu, GuanQun ;
Gack, Michaela U. .
NATURE REVIEWS IMMUNOLOGY, 2020, 20 (07) :397-398
[2]   Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease [J].
Agostini, Maria L. ;
Andres, Erica L. ;
Sims, Amy C. ;
Graham, Rachel L. ;
Sheahan, Timothy P. ;
Lu, Xiaotao ;
Smith, Everett Clinton ;
Case, James Brett ;
Feng, Joy Y. ;
Jordan, Robert ;
Ray, Adrian S. ;
Cihlar, Tomas ;
Siegel, Dustin ;
Mackman, Richard L. ;
Clarke, Michael O. ;
Baric, Ralph S. ;
Denison, Mark R. .
MBIO, 2018, 9 (02)
[3]   Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer [J].
Avanzato, Victoria A. ;
Matson, M. Jeremiah ;
Seifert, Stephanie N. ;
Pryce, Rhys ;
Williamson, Brandi N. ;
Anzick, Sarah L. ;
Barbian, Kent ;
Judson, Seth D. ;
Fischer, Elizabeth R. ;
Martens, Craig ;
Bowden, Thomas A. ;
de Wit, Emmie ;
Riedo, Francis X. ;
Munster, Vincent J. .
CELL, 2020, 183 (07) :1901-+
[4]   Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient [J].
Baang, Ji Hoon ;
Smith, Christopher ;
Mirabelli, Carmen ;
Valesano, Andrew L. ;
Manthei, David M. ;
Bachman, Michael A. ;
Wobus, Christiane E. ;
Adams, Michael ;
Washer, Laraine ;
Martin, Emily T. ;
Lauring, Adam S. .
JOURNAL OF INFECTIOUS DISEASES, 2021, 223 (01) :23-27
[5]   RNA editing by adenosine deaminases that act on RNA [J].
Bass, BL .
ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :817-846
[6]   Autoantibodies against type I IFNs in patients with life-threatening COVID-19 [J].
Bastard, Paul ;
Rosen, Lindsey B. ;
Zhang, Qian ;
Michailidis, Eleftherios ;
Hoffmann, Hans-Heinrich ;
Zhang, Yu ;
Dorgham, Karim ;
Philippot, Quentin ;
Rosain, Jeremie ;
Beziat, Vivien ;
Manry, Jeremy ;
Shaw, Elana ;
Haljasmagi, Liis ;
Peterson, Part ;
Lorenzo, Lazaro ;
Bizien, Lucy ;
Trouillet-Assant, Sophie ;
Dobbs, Kerry ;
de Jesus, Adriana Almeida ;
Belot, Alexandre ;
Kallaste, Anne ;
Catherinot, Emilie ;
Tandjaoui-Lambiotte, Yacine ;
Le Pen, Jeremie ;
Kerner, Gaspard ;
Bigio, Benedetta ;
Seeleuthner, Yoann ;
Yang, Rui ;
Bolze, Alexandre ;
Spaan, Andras N. ;
Delmonte, Ottavia M. ;
Abers, Michael S. ;
Aiuti, Alessandro ;
Casari, Giorgio ;
Lampasona, Vito ;
Piemonti, Lorenzo ;
Ciceri, Fabio ;
Bilguvar, Kaya ;
Lifton, Richard P. ;
Vasse, Marc ;
Smadja, David M. ;
Migaud, Melanie ;
Hadjadj, Jerome ;
Terrier, Benjamin ;
Duffy, Darragh ;
Quintana-Murci, Lluis ;
van de Beek, Diederik ;
Roussel, Lucie ;
Vinh, Donald C. ;
Tangye, Stuart G. .
SCIENCE, 2020, 370 (6515) :423-+
[7]   Mutagenesis of Coronavirus nsp14 Reveals Its Potential Role in Modulation of the Innate Immune Response [J].
Becares, Martina ;
Pascual-Iglesias, Alejandro ;
Nogales, Aitor ;
Sola, Isabel ;
Enjuanes, Luis ;
Zuniga, Sonia .
JOURNAL OF VIROLOGY, 2016, 90 (11) :5399-5414
[8]   RNA 3′-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex [J].
Bouvet, Mickael ;
Imbert, Isabelle ;
Subissi, Lorenzo ;
Gluais, Laure ;
Canard, Bruno ;
Decroly, Etienne .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (24) :9372-9377
[9]   Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19 [J].
Brown, Eric L. ;
Essigmann, Heather T. .
MSPHERE, 2021, 6 (02) :1-6
[10]  
Centers for Disease Control and Prevention, 2022, COVID DAT TRACK