Kinetic Studies and Temperature-Induced Morphological Changes of Peptide Decorated Nano-Objects via Polymerization-Induced Self-Assembly

被引：1

作者：

Benkhaled, Belkacem Tarek ^{[1
]}

Chouirfa, Hamza ^{[1
]}

Vezenkov, Lubomir ^{[2
]}

Gomri, Chaimaa ^{[1
]}

Chaix, Arnaud ^{[1
]}

Subra, Gilles ^{[2
]}

Ladmiral, Vincent ^{[3
]}

Semsarilar, Mona ^{[1
]}

机构：

[1] Univ Montpellier, Inst Europeen Membranes, IEM, CNRS,ENSCM, Montpellier, France

[2] Univ Montpellier, Inst Biomol Max Mousseron, IBMM, CNRS,ENSCM, Montpellier, France

[3] Univ Montpellier, Inst Charles Gerhardt Montpellier, ENSCM, CNRS, Montpellier, France

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 2023年 / 224卷 / 20期

关键词：

colloidal particles; peptide-polymer conjugates; PISA; SAP; self-assembly; POLYELECTROLYTE-STABILIZED NANOPARTICLES; RAFT DISPERSION POLYMERIZATION; RADICAL POLYMERIZATION; WATER; NANOTUBES;

D O I：

10.1002/macp.202300178

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In the present work, combining polymerization-induced self-assembly (PISA) with self-assembling peptides (SAPs) peptide-polymer hybrid nanostructures are prepared, harnessing the advantages of PISA and the self-assembling driving force of SAPs. A tripeptide methacrylamide denoted as MAm-GFF, where MAm, G, and F stand for methacrylamide, glycine, and phenylalanine, is copolymerized with glycerol monomethacrylate (GMA) by reversible addition-fragmentation chain transfer polymerization (RAFT) in dimethylformamide to produce a P(GMA(62)-stat-(MAm-GFF)(7)) macromolecular chain transfer agent (macro-CTA). This peptide-containing macro-CTA is then successfully chain-extended with poly(2-hydroxypropyl methacrylate) (PHPMA) by aqueous dispersion PISA, forming P(GMA(62)-stat-(MAm-GFF)(7))-b-PHPMA(27) self-assembled objects. The impacts of temperature and monomer conversion on the morphologies formed during the PISA process are investigated by analyzing samples withdrawn at different time during the polymerization of HPMA using transmission electron microscopy (TEM) and dynamic light scattering (DLS) at different temperatures (5-70 & DEG;C).

引用

页数：8

共 63 条

[1] STABILIZATION OF BETA-RIBBON STRUCTURES IN PEPTIDES USING DISULFIDE BONDS [J].

ABERLE, AM ;

REDDY, HK ;

HEEB, NV ;

NAMBIAR, KP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 200 (01) :102-107

[2] Hierarchical self-assembly of chiral rod-like molecules as a model for peptide β-sheet tapes, ribbons, fibrils, and fibers [J].

Aggeli, A ;

Nyrkova, IA ;

Bell, M ;

Harding, R ;

Carrick, L ;

McLeish, TCB ;

Semenov, AN ;

Boden, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (21) :11857-11862

[3] Self-assembled nanotubes from single fluorescent amino acid [J].

Babar, Dipak Gorakh ;

Sarkar, Sabyasachi .

APPLIED NANOSCIENCE, 2017, 7 (3-4) :101-107

[4] Self-Assembly of Aromatic Amino Acid Enantiomers into Supramolecular Materials of High Rigidity [J].

Bera, Santu ;

Xue, Bin ;

Rehak, Pavel ;

Jacoby, Guy ;

Ji, Wei ;

Shimon, Linda J. W. ;

Beck, Roy ;

Kral, Petr ;

Cao, Yi ;

Gazit, Ehud .

ACS NANO, 2020, 14 (02) :1694-1706

[5] Predictive Phase Diagrams for RAFT Aqueous Dispersion Polymerization: Effect of Block Copolymer Composition, Molecular Weight, and Copolymer Concentration [J].

Blanazs, A. ;

Ryan, A. J. ;

Armes, S. P. .

MACROMOLECULES, 2012, 45 (12) :5099-5107

[6] Sterilizable Gels from Thermoresponsive Block Copolymer Worms [J].

Blanazs, Adam ;

Verber, Robert ;

Mykhaylyk, Oleksandr O. ;

Ryan, Anthony J. ;

Heath, Jason Z. ;

Douglas, C. W. Ian ;

Armes, Steven P. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (23) :9741-9748

[7] Mechanistic Insights for Block Copolymer Morphologies: How Do Worms Form Vesicles? [J].

Blanazs, Adam ;

Madsen, Jeppe ;

Battaglia, Giuseppe ;

Ryan, Anthony J. ;

Armes, Steven P. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (41) :16581-16587

[8] Amphiphilic block copolymer nano-fibers via RAFT-mediated polymerization in aqueous dispersed system [J].

Boisse, Stephanie ;

Rieger, Jutta ;

Belal, Khaled ;

Di-Cicco, Aurelie ;

Beaunier, Patricia ;

Li, Min-Hui ;

Charleux, Bernadette .

CHEMICAL COMMUNICATIONS, 2010, 46 (11) :1950-1952

[9] Temperature-induced self-assembly and metal-ion stabilization of histidine functional block copolymers [J].

Brisson, Emma R. L. ;

Griffith, James C. ;

Bhaskaran, Ayana ;

Franks, George, V ;

Connal, Luke A. .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2019, 57 (18) :1964-1973

[10] In Situ Small-Angle X-ray Scattering Studies During Reversible Addition-Fragmentation Chain Transfer Aqueous Emulsion Polymerization [J].

Brotherton, Emma E. ;

Hatton, Fiona L. ;

Cockram, Amy A. ;

Derry, Matthew J. ;

Czajka, Adam ;

Cornel, Erik J. ;

Topham, Paul D. ;

Mykhaylyk, Oleksandr O. ;

Armes, Steven P. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 141 (34) :13664-13675

← 1 2 3 4 5 6 7 →