Autoantigen profiling reveals a shared post-COVID signature in fully recovered and long COVID patients

被引：26

作者：

Bodansky, Aaron ^{[1
]}

Wang, Chung -Yu ^{[2
]}

Saxena, Aditi ^{[2
]}

Mitchell, Anthea ^{[2
]}

Kung, Andrew F. ^{[3
]}

Takahashi, Saki ^{[4
]}

Anglin, Khamal ^{[5
]}

Huang, Beatrice ^{[4
]}

Hoh, Rebecca ^{[4
]}

Lu, Scott ^{[5
]}

Goldberg, Sarah A. ^{[5
]}

Romero, Justin ^{[4
]}

Tran, Brandon ^{[4
]}

Kirtikar, Raushun ^{[4
]}

Grebe, Halle ^{[4
]}

So, Matthew ^{[4
]}

Greenhouse, Bryan ^{[4
]}

Durstenfeld, Matthew S. ^{[6
]}

Hsue, Priscilla Y. ^{[6
]}

Hellmuth, Joanna ^{[7
]}

Kelly, J. Daniel ^{[5
]}

Martin, Jeffrey N. ^{[5
]}

Anderson, Mark S. ^{[8
,9
]}

Deeks, Steven G. ^{[4
]}

Henrich, Timothy J. ^{[10
]}

DeRisi, Joseph L. ^{[3
]}

Peluso, Michael J. ^{[4
,11
]}

机构：

[1] UCSF, Div Pediat Crit Care Med, San Francisco, CA USA

[2] Chan Zuckerberg Biohub Network, San Francisco, CA USA

[3] UCSF, Dept Biochem & Biophys, San Francisco, CA USA

[4] UCSF, Dept Med, Div HIV Infect Dis & Global Med, San Francisco, CA USA

[5] UCSF, Dept Epidemiol & Biostat, San Francisco, CA USA

[6] UCSF, Dept Med, Div Cardiol, San Francisco, CA USA

[7] UCSF, Dept Neurol, San Francisco, CA USA

[8] UCSF, Diabet Ctr, San Francisco, CA USA

[9] UCSF, Dept Med, San Francisco, CA USA

[10] UCSF, Dept Med, Div Expt Med, San Francisco, CA USA

[11] UCSF, Div HIV Infect Dis & Global Med, 1001 Potrero Ave, Bldg 80, 4th Floor,, San Francisco, CA 94143 USA

来源：

JCI INSIGHT | 2023年 / 8卷 / 11期

关键词：

D O I：

10.1172/jci.insight.169515

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Some individuals do not return to baseline health following SARS-CoV-2 infection, leading to a condition known as long COVID. The underlying pathophysiology of long COVID remains unknown. Given that autoantibodies have been found to play a role in severity of SARS-CoV-2 infection and certain other post-COVID sequelae, their potential role in long COVID is important to investigate. Here, we apply a well-established, unbiased, proteome-wide autoantibody detection technology (T7 phage-display assay with immunoprecipitation and next-generation sequencing, PhIP-Seq) to a robustly phenotyped cohort of 121 individuals with long COVID, 64 individuals with prior COVID-19 who reported full recovery, and 57 pre-COVID controls. While a distinct autoreactive signature was detected that separated individuals with prior SARS-CoV-2 infection from those never exposed to SARS-CoV-2, we did not detect patterns of autoreactivity that separated individuals with long COVID from individuals fully recovered from COVID-19. These data suggest that there are robust alterations in autoreactive antibody profiles due to infection; however, no association of autoreactive antibodies and long COVID was apparent by this assay.

引用

页数：10

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