hiPSC-Neural Stem/Progenitor Cell Transplantation Therapy for Spinal Cord Injury

被引：4

作者：

Du, Xiaofeng ^{[1
,2
]}

Amponsah, Asiamah Ernest ^{[1
,2
]}

Kong, Desheng ^{[1
,2
]}

He, Jingjing ^{[1
,2
]}

Ma, Zhenhuan ^{[1
,2
]}

Ma, Jun ^{[1
,2
,3
]}

Cui, Huixian ^{[1
,2
,3
]}

机构：

[1] Hebei Med Univ, Natl Univ Ireland, Galway Stem Cell Res Ctr, Shijiazhuang 050017, Hebei, Peoples R China

[2] Hebei Res Ctr Stem Cell Med Translat Engn, Shijiazhuang 050017, Hebei, Peoples R China

[3] Hebei Med Univ, Human Anat Dept, Shijiazhuang 050017, Hebei, Peoples R China

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2023年 / 18卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Spinal cord injury; hiPSC; neural stem cell; neural progenitor cell; transplantation; neuroprotective effects; PLURIPOTENT STEM-CELLS; HUMAN BONE-MARROW; PROGENITOR CELLS; FUNCTIONAL RECOVERY; ADIPOSE-TISSUE; MOTOR-NEURONS; ADULT-RAT; DIFFERENTIATE; REPAIR; FIBROBLASTS;

D O I：

10.2174/1574888X17666220509222520

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Spinal cord injury (SCI) is a catastrophic event that incurs substantial personal and social costs. The complex pathophysiology associated with SCI often limits the regeneration of nerve tissue at the injured site and leads to permanent nerve damage. With advances in stem cell biology, the field of regenerative medicine offers the hope of solving this challenging problem. Neural stem/progenitor cells (NSPCs) possess nerve regenerative and neuroprotective effects, and transplanting NSPCs in their optimized form into an injured area holds promising therapeutic potential for SCI. In this review, we summarize the advantages and disadvantages of NSPCs derived from different sources while highlighting the utility of NSPCs derived from induced pluripotent stem cells, an NSPC source with superior advantages, according to data from in vivo animal models and the latest clinical trials.

引用

页码：487 / 498

页数：12

共 90 条

[11] Relating Histopathology and Mechanical Strain in Experimental Contusion Spinal Cord Injury in a Rat Model [J].