Multi-nuclear sodium, diffusion, and perfusion MRI in human gliomas

被引：10

作者：

Cho, Nicholas S. ^{[1
,2
,3
,4
]}

Sanvito, Francesco ^{[1
,2
]}

Thakuria, Shruti ^{[1
,2
]}

Wang, Chencai ^{[1
,2
]}

Hagiwara, Akifumi ^{[1
,2
,5
]}

Nagaraj, Raksha ^{[1
,2
]}

Oshima, Sonoko ^{[1
,2
]}

Kolkovsky, Alfredo Lopez L. ^{[1
,2
,6
]}

Lu, Jianwen ^{[1
,2
]}

Raymond, Catalina ^{[1
,2
]}

Liau, Linda M. ^{[7
]}

Everson, Richard G. ^{[7
]}

Patel, Kunal S. ^{[7
]}

Kim, Won ^{[7
]}

Yang, Isaac ^{[7
]}

Bergsneider, Marvin ^{[7
]}

Nghiemphu, Phioanh L. ^{[8
,9
]}

Lai, Albert ^{[8
,9
]}

Nathanson, David A. ^{[10
]}

Cloughesy, Timothy F. ^{[8
,9
]}

Ellingson, Benjamin M. ^{[1
,2
,3
,7
,11
,12
,13
,14
]}

机构：

[1] Univ Calif Los Angeles, UCLA Brain Tumor Imaging Lab BTIL, Ctr Comp Vis & Imaging Biomarkers, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Dept Bioengn, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Med Scientist Training Program, Los Angeles, CA USA

[5] Juntendo Univ, Sch Med, Dept Radiol, Tokyo, Japan

[6] Inst Myol, Neuromuscular Invest Ctr, NMR Lab, Paris, France

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA

[8] Univ Calif Los Angeles, David Geffen Sch Med, UCLA Neurooncol Program, Los Angeles, CA USA

[9] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA USA

[10] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA USA

[11] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[12] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, UCLA Brain Tumor Imaging Lab BTIL Prof Radiol Psyc, 924 Westwood Blvd Suite 615, Los Angeles, CA 90024 USA

[13] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat, UCLA Brain Tumor Imaging Lab BTIL Prof Radiol Psyc, 924 Westwood Blvd Suite 615, Los Angeles, CA 90024 USA

[14] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, UCLA Brain Tumor Imaging Lab BTIL Prof Radiol Psyc, 924 Westwood Blvd Suite 615, Los Angeles, CA 90024 USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 2023年 / 163卷 / 02期

关键词：

Glioma; Sodium MRI; Diffusion MRI; Dynamic susceptibility contrast perfusion MRI; Multinuclear MRI; Glioblastoma; CHEMOTHERAPEUTIC RESPONSE; BRAIN; GLIOBLASTOMA; GRADE; TUMORS; SURVIVAL; NECROSIS; VOLUME; CELL; TMZ;

D O I：

10.1007/s11060-023-04363-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PurposeThere is limited knowledge about the associations between sodium and proton MRI measurements in brain tumors. The purpose of this study was to quantify intra- and intertumoral correlations between sodium, diffusion, and perfusion MRI in human gliomas.MethodsTwenty glioma patients were prospectively studied on a 3T MRI system with multinuclear capabilities. Three mutually exclusive tumor volumes of interest (VOIs) were segmented: contrast-enhancing tumor (CET), T2/FLAIR hyperintense non-enhancing tumor (NET), and necrosis. Median and voxel-wise associations between apparent diffusion coefficient (ADC), normalized relative cerebral blood volume (nrCBV), and normalized sodium measurements were quantified for each VOI.ResultsBoth relative sodium concentration and ADC were significantly higher in areas of necrosis compared to NET (P = 0.003 and P = 0.008, respectively) and CET (P = 0.02 and P = 0.02). Sodium concentration was higher in CET compared to NET (P = 0.04). Sodium and ADC were higher in treated compared to treatment-naive gliomas within NET (P = 0.006 and P = 0.01, respectively), and ADC was elevated in CET (P = 0.03). Median ADC and sodium concentration were positively correlated across patients in NET (r = 0.77, P < 0.0001) and CET (r = 0.84, P < 0.0001), but not in areas of necrosis (r = 0.45, P = 0.12). Median nrCBV and sodium concentration were negatively correlated across patients in areas of NET (r=-0.63, P = 0.003). Similar associations were observed when examining voxel-wise correlations within VOIs.ConclusionSodium MRI is positively correlated with proton diffusion MRI measurements in gliomas, likely reflecting extracellular water. Unique areas of multinuclear MRI contrast may be useful in future studies to understand the chemistry of the tumor microenvironment.

引用

页码：417 / 427

页数：11

共 41 条

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