Crosstalk between Oxidative Stress and Aging in Neurodegeneration Disorders

被引：30
作者：
Abdelhamid, Rehab F. F. [1 ,2 ]
Nagano, Seiichi [1 ,2 ]
机构：
[1] Osaka Univ, Grad Sch Med, Dept Neurol, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Med, Dept Neurotherapeut, Suita, Osaka 5650871, Japan
来源：
CELLS | 2023年 / 12卷 / 05期
关键词：
oxidative stress; free radical; aging; neurodegenerative diseases; AMYOTROPHIC-LATERAL-SCLEROSIS; ISCHEMIA-REPERFUSION INJURY; FACTOR-KAPPA-B; PARKINSONS-DISEASE; AMYLOID-BETA; BIOLOGICAL-MATERIALS; IONIZING-RADIATION; LIPID-PEROXIDATION; ALPHA-SYNUCLEIN; HEAVY-METALS;
D O I：
10.3390/cells12050753
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The world population is aging rapidly, and increasing lifespan exacerbates the burden of age-related health issues. On the other hand, premature aging has begun to be a problem, with increasing numbers of younger people suffering aging-related symptoms. Advanced aging is caused by a combination of factors: lifestyle, diet, external and internal factors, as well as oxidative stress (OS). Although OS is the most researched aging factor, it is also the least understood. OS is important not only in relation to aging but also due to its strong impact on neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer's disease (AD), and Parkinson's disease (PD). In this review, we will discuss the aging process in relation to OS, the function of OS in neurodegenerative disorders, and prospective therapeutics capable of relieving neurodegenerative symptoms associated with the pro-oxidative condition.
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页数：16
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