Noradrenergic modulation of stress resilience

被引：7
作者：
Zhai, Xiaojing [1 ,2 ,3 ]
Zhou, Dongyu [1 ,2 ,3 ]
Han, Yi [1 ,2 ,3 ]
Han, Ming-Hu [4 ,5 ]
Zhang, Hongxing [1 ,2 ,3 ]
机构：
[1] Xuzhou Med Univ, Jiangsu Prov Key Lab Anesthesiol, Xuzhou 221004, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Jiangsu Prov Key Lab Anesthesia & Analgesia Applic, Xuzhou 221004, Jiangsu, Peoples R China
[3] Xuzhou Med Univ, NMPA Key Lab Res & Evaluat Narcot & Psychotrop Dru, Xuzhou 221004, Jiangsu, Peoples R China
[4] Chinese Acad Sci, Shenzhen Inst Adv Technol, Fac Life & Hlth Sci, Dept Mental Hlth & Publ Hlth, Beijing 518055, Guangdong, Peoples R China
[5] Icahn Sch Med Mt Sinai, Dept Pharmacol Sci, New York, NY 10029 USA
来源：
PHARMACOLOGICAL RESEARCH | 2023年 / 187卷
基金：
中国国家自然科学基金;
关键词：
Locus coeruleus; Norepinephrine; Resilience; Antidepressant; Neural circuit; Molecular mechanisms; INTRANASAL NEUROPEPTIDE-Y; MESSENGER-RNA LEVELS; LOCUS-COERULEUS DISCHARGE; SOCIAL DEFEAT STRESS; VOLUNTARY EXERCISE; NUCLEUS-ACCUMBENS; DOPAMINE NEURONS; GENE-EXPRESSION; GALANIN; DEPRESSION;
D O I：
10.1016/j.phrs.2022.106598
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Resilience represents an active adaption process in the face of adversity, trauma, tragedy, threats, or significant sources of stress. Investigations of neurobiological mechanisms of resilience opens an innovative direction for preclinical research and drug development for various stress-related disorders. The locus coeruleus norepinephrine system has been implicated in mediating stress susceptibility versus resilience. It has attracted increasing attention over the past decades with the revolution of modern neuroscience technologies. In this review article, we first briefly go over resilience-related concepts and introduce rodent paradigms for segregation of susceptibility and resilience, then highlight recent literature that identifies the neuronal and molecular substrates of active resilience in the locus coeruleus, and discuss possible future directions for resilience investigations.
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页数：10
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