Sensorimotor network connectivity correlates with motor improvement after repetitive transcranial magnetic stimulation in patients with Parkinson's disease

被引：6
作者：
Chi, Shumei [1 ]
Wen, Xinrui [3 ]
Yu, Yang [4 ]
Wang, Guanjun [2 ,5 ]
Zhang, Jie [6 ,7 ]
Xue, Chuang [2 ,8 ]
Zhang, Xiaoying [1 ]
Wang, Zheng [1 ]
Gesang, Meiduo [1 ]
Chen, Jiefang [1 ]
Wu, Sha [1 ]
Jin, Man [1 ]
Liu, Jian [2 ,9 ]
Luo, Benyan [3 ]
机构：
[1] Zhejiang Univ, Dept Neurol, Affiliated Mental Hlth Ctr, Sch Med, Hangzhou, Peoples R China
[2] Zhejiang Univ, Hangzhou Peoples Hosp 7, Sch Med, Hangzhou 310000, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Neurol, Hangzhou, Peoples R China
[4] Zhejiang Univ, Affiliated Sir Run Shaw Hosp, Sch Med, Dept Phys Med & Rehabil, Hangzhou, Peoples R China
[5] Zhejiang Univ, Affiliated Mental Hlth Ctr, Dept Radiol, Sch Med, Hangzhou, Peoples R China
[6] Hangzhou Med Coll, Rehabil Med Ctr, Hangzhou, Peoples R China
[7] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Rehabil Res Inst Zhejiang Prov, Hangzhou, Peoples R China
[8] Zhejiang Univ, Affiliated Mental Hlth Ctr, Dept Physiotherapy Treatment Ctr, Sch Med, Hangzhou 310000, Peoples R China
[9] Zhejiang Univ, Affiliated Mental Hlth Ctr, Sch Med, Hangzhou 310000, Peoples R China
来源：
PARKINSONISM & RELATED DISORDERS | 2023年 / 106卷
基金：
中国国家自然科学基金;
关键词：
Repetitive transcranial magnetic stimulation; Parkinson ?s disease; Degree centrality; Functional connectivity; Sensorimotor network; HIGH-FREQUENCY RTMS; FUNCTIONAL CONNECTIVITY; SUPPLEMENTARY; AREA; HUBS; STATE;
D O I：
10.1016/j.parkreldis.2022.11.010
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Emerging evidence suggests that repetitive transcranial magnetic stimulation (rTMS) generally improves Parkinson's disease (PD) motor symptoms. However, personal responses to rTMS might be different. In this study, we explore the connectivity changes in PD patients with different responses to rTMS. Methods: Among PD patients, 25 were treated with 10Hz-rTMS and seven were with sham rTMS over the sup-plementary motor area for 10 days. Resting-state functional connectivity magnetic resonance imaging (rs-fMRI) was performed in PD patients before and after rTMS stimulation. Neuropsychological scales such as Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) were collected synchronously with rs-fMRI. To explore the connectivity changes after rTMS, degree centrality was calculated. Results: 13 out of 25 participants were responsive to 10Hz rTMS. Degree centrality patterns in the left sensori-motor regions are primarily responsible for the differences between responsive and non-responsive individuals. Improvement in motor symptoms was substantially related to the baseline degree centrality in the left PreCG and the left PoCG. The performance in distinguishing non-responders from responders was further validated by the ROC analysis utilizing DC characteristics. Lastly, we found that connectivity increased in left PreCG and PoCG in patients with a better response to the rTMS. Conclusion: Taken together, these results suggest that the sensorimotor network is involved in the motor improvement following rTMS treatment, with patients with lower sensorimotor connectivity showing a tendency for greater motor improvement to HF-rTMS.
引用
收藏
页数：7
相关论文
共 32 条
[1]   Network modulation in the treatment of Parkinson's disease [J].
Asanuma, Kotaro ;
Tang, Chengke ;
Ma, Yilong ;
Dhawan, Vijay ;
Mattis, Paul ;
Edwards, Christine ;
Kaplitt, Michael G. ;
Feigin, Andrew ;
Eidelberg, David .
BRAIN, 2006, 129 :2667-2678
[2]   Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease [J].
Bockova, Martina ;
Vytvarova, Eva ;
Lamos, Martin ;
Klimes, Petr ;
Jurak, Pavel ;
Halamek, Josef ;
Goldemundova, Sabina ;
Balaz, Marek ;
Rektor, Ivan .
HUMAN BRAIN MAPPING, 2021, 42 (17) :5626-5635
[3]   Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease [J].
Buckner, Randy L. ;
Sepulcre, Jorge ;
Talukdar, Tanveer ;
Krienen, Fenna M. ;
Liu, Hesheng ;
Hedden, Trey ;
Andrews-Hanna, Jessica R. ;
Sperling, Reisa A. ;
Johnson, Keith A. .
JOURNAL OF NEUROSCIENCE, 2009, 29 (06) :1860-1873
[4]  
Chen SY, 2010, TZU CHI MED J, V22, P73
[5]   Predict initial subthalamic nucleus stimulation outcome in Parkinson's disease with brain morphology [J].
Chen, Yingchuan ;
Zhu, Guanyu ;
Liu, Yuye ;
Liu, Defeng ;
Yuan, Tianshuo ;
Zhang, Xin ;
Jiang, Yin ;
Du, Tingting ;
Zhang, Jianguo .
CNS NEUROSCIENCE & THERAPEUTICS, 2022, 28 (05) :667-676
[6]   Effects of Repetitive Transcranial Magnetic Stimulation on Motor Symptoms in Parkinson Disease A Systematic Review and Meta-analysis [J].
Chou, Ying-hui ;
Hickey, Patrick T. ;
Sundman, Mark ;
Song, Allen W. ;
Chen, Nan-kuei .
JAMA NEUROLOGY, 2015, 72 (04) :432-440
[7]   Use of Functional Magnetic Resonance Imaging to Assess How Motor Phenotypes of Parkinson's Disease Respond to Deep Brain Stimulation [J].
DiMarzio, Marisa ;
Madhavan, Radhika ;
Joel, Suresh ;
Hancu, Ileana ;
Fiveland, Eric ;
Prusik, Julia ;
Gillogly, Michael ;
Rashid, Tanweer ;
MacDonell, Jacquelyn ;
Ashe, Jeffrey ;
Telkes, Ilknur ;
Feustel, Paul ;
Staudt, Michael D. ;
Shin, Damian S. ;
Durphy, Jennifer ;
Hwang, Roy ;
Hanspal, Era ;
Pilitsis, Julie G. .
NEUROMODULATION, 2020, 23 (04) :515-524
[8]   Opposite effects of one session of 1 Hz rTMS on functional connectivity between pre-supplementary motor area and putamen depending on the dyskinesia state in Parkinson's disease [J].
Flamez, Anja ;
Wu, Guo-Rong ;
Wiels, Wietse ;
Van Schuerbeek, Peter ;
De Mey, Johan ;
De Keyser, Jacques ;
Baeken, Chris .
CLINICAL NEUROPHYSIOLOGY, 2021, 132 (04) :851-856
[9]   High-frequency rTMS over the supplementary motor area for treatment of Parkinson's disease [J].
Hamada, Masashi ;
Ugawa, Yoshikazu ;
Tsuji, Sadatoshi .
MOVEMENT DISORDERS, 2008, 23 (11) :1524-1531
[10]   High-frequency rTMS over the supplementary motor area improves bradykinesia in Parkinson's disease: Subanalysis of double-blind sham-controlled study [J].
Hamada, Masashi ;
Ugawa, Yoshikazu ;
Tsuji, Sadatoshi .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2009, 287 (1-2) :143-146
1234