Is Zn2+ the new Ca2+ for TRPC6 channels in the myocardium?

被引：2

作者：

Dietrich, Alexander ^{[1
,2
,3
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Walther Straub Inst Pharmacol & Toxicol, Munich, Germany

[2] Ludwig Maximilians Univ Munchen, German Ctr Lung Res DZL, Munich, Germany

[3] Ludwig Maximilians Univ Munchen, Walther Straub Inst Pharmacol & Toxicol, Nussbaumstr 26, D-80336 Munich, Germany

来源：

CELL CALCIUM | 2023年 / 109卷

关键词：

Cardiomyocyte contraction; Zinc ions; G-protein coupled receptor kinase interacting; protein; 1; Adenylate cyclase; cAMP; Diacylglycerol; ZINC;

D O I：

10.1016/j.ceca.2022.102674

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transient Receptor Potential (TRP) channels are nonselective cation channels, which are mainly permeable to Ca2+ and Na+ but many of them are also permeable to Zn2+. In a new elegant study, a Zn2+-dependent pathway involving the TRP member TRPC6 and alpha 1-as well as beta-adrenoceptors (AR) was dissected in rodent myocytes. Norepinephrine-mediated activation of alpha 1-AR induces Zn2+ influx through TRPC6 channels, which reinforces beta-AR-mediated positive inotropy and may help patients with heart failure. This work encourages a closer look at the consequences of Zn2+ permeation through TRP channels in human health and disease.

引用

页数：2

共 10 条

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