Is Zn2+ the new Ca2+ for TRPC6 channels in the myocardium?

被引：2
|
作者：
Dietrich, Alexander [1 ,2 ,3 ]
机构：
[1] Ludwig Maximilians Univ Munchen, Walther Straub Inst Pharmacol & Toxicol, Munich, Germany
[2] Ludwig Maximilians Univ Munchen, German Ctr Lung Res DZL, Munich, Germany
[3] Ludwig Maximilians Univ Munchen, Walther Straub Inst Pharmacol & Toxicol, Nussbaumstr 26, D-80336 Munich, Germany
来源：
CELL CALCIUM | 2023年 / 109卷
关键词：
Cardiomyocyte contraction; Zinc ions; G-protein coupled receptor kinase interacting; protein; 1; Adenylate cyclase; cAMP; Diacylglycerol; ZINC;
D O I：
10.1016/j.ceca.2022.102674
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Transient Receptor Potential (TRP) channels are nonselective cation channels, which are mainly permeable to Ca2+ and Na+ but many of them are also permeable to Zn2+. In a new elegant study, a Zn2+-dependent pathway involving the TRP member TRPC6 and alpha 1-as well as beta-adrenoceptors (AR) was dissected in rodent myocytes. Norepinephrine-mediated activation of alpha 1-AR induces Zn2+ influx through TRPC6 channels, which reinforces beta-AR-mediated positive inotropy and may help patients with heart failure. This work encourages a closer look at the consequences of Zn2+ permeation through TRP channels in human health and disease.
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页数：2
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