Visible-light-enabled cascade cross-dehydrogenative-coupling/cyclization to construct α-chromone substituted α-amino acid derivatives

被引：7

作者：

Zhu, Zhi-Qiang ^{[1
]}

Hu, Jia-Yu ^{[1
]}

Xie, Zong-Bo ^{[1
]}

Le, Zhang-Gao ^{[1
]}

机构：

[1] East China Univ Technol, Sch Chem & Mat Sci, Jiangxi Prov Key Lab Synthet Chem, Nanchang 330013, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 60卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ACCESS; FLAVONES;

D O I：

10.1039/d3cc04107g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Organophotocatalytic cascade cross-dehydrogenative-coupling/cyclization reaction of o-hydroxyarylenaminones with alpha-amino acid derivatives for the construction of alpha-chromone substituted alpha-amino acid derivatives was developed. Various N-arylglycine esters, amides and dipeptides underwent the cascade cyclization reaction well with o-hydroxyarylenaminones to afford the corresponding 3-aminoalkyl chromones in good to excellent yields. This approach consists of visible-light-promoted oxidation of alpha-amino acid derivatives, the Mannich reaction, and intramolecular nucleophilic cyclization under acidic conditions, and features a wide reaction scope, a simple operation and mild reaction conditions, which may have the potential to be used for the synthesis of bioactive molecules. Photocatalytic cascade cross-dehydrogenative-coupling/cyclization reaction of o-hydroxyarylenaminones with N-arylglycine derivatives for the construction of alpha-chromone substituted alpha-amino acid derivatives was developed.

引用

页码：106 / 109

页数：4

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