Neutralizing Immunity Against Antigenically Advanced Omicron BA.5 in Children After SARS-CoV-2 Infection

被引：0

作者：

Belongia, Edward A. ^{[1
,5
]}

Petrie, Joshua G. ^{[1
]}

Feldstein, Leora R. ^{[3
]}

Guan, Lizheng ^{[2
]}

Halfmann, Peter J. ^{[2
]}

King, Jennifer P.

Neumann, Gabriele ^{[2
]}

Pattinson, David ^{[2
]}

Rolfes, Melissa A. ^{[4
]}

Mclean, Huong Q. ^{[1
]}

Kawaoka, Yoshihiro ^{[2
]}

机构：

[1] Marshfield Clin Res Inst, Ctr Clin Epidemiol & Populat Hlth, Marshfield, WI USA

[2] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI USA

[3] CDCP, Coronavirus & Other Resp Viruses Div, Atlanta, GA USA

[4] CDCP, Influenza Div, Atlanta, GA USA

[5] Marshfield Clin Res Inst, Ctr Clin Epidemiol & Populat Hlth, 1000 N Oak Ave ML2, Marshfield, WI 54449 USA

来源：

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2024年 / 13卷 / 01期

关键词：

cross-neutralization; neutralizing antibodies; Omicron; SARS-CoV-2; infection;

D O I：

10.1093/jpids/piad109

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We assessed serum neutralization of Omicron BA.5 in children following SARS-CoV-2 infection during the Delta or Omicron BA.1/BA.2 variant period. Convalescent BA.5 titers were higher following infections during the Omicron BA.1/BA.2 vs Delta variant period, and in vaccinated vs unvaccinated children. Titers against BA.5 did not differ by age group. We assessed serum neutralization against antigenically advanced Omicron BA.5 in children following SARS-CoV-2 infection with Delta and Omicron BA.1/2 variants. Post-infection titers to BA.5 were significantly higher for infections during the Omicron period and in vaccinated vs unvaccinated children.

引用

页码：100 / 104

页数：5

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