Osteopontin regulates the growth and invasion of liver cancer cells via DTL

被引：1
作者：
Liu, Zhiyong [1 ,2 ]
Yang, Guang [3 ]
Yi, Xiaoyu [1 ,2 ]
Zhang, Shijie [1 ,2 ]
Feng, Zhibo [1 ,2 ]
Cui, Xudong [1 ,2 ]
Chen, Feilong [1 ,2 ]
Yu, Lei [1 ,2 ,4 ,5 ]
机构：
[1] Guangxi Acad Med Sci, Dept Gen Intervent Radiol, Nanning 530021, Peoples R China
[2] Peoples Hosp Guangxi Zhuang Autonomous Reg, Nanning 530021, Peoples R China
[3] Sun Yat Sen Univ, Ctr Canc, Dept Imaging & Intervent Radiol, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China
[4] Guangxi Acad Med Sci, Dept Gen Intervent Radiol, 6 Taoyuan Rd, Nanning 530021, Guangxi Zhuang, Peoples R China
[5] Peoples Hosp Guangxi Zhuang Autonomous Reg, 6 Taoyuan Rd, Nanning 530021, Guangxi Zhuang, Peoples R China
来源：
ONCOLOGY LETTERS | 2023年 / 26卷 / 05期
关键词：
osteopontin; denticleless E3 ubiquitin protein ligase homolog; DTL; liver cancer cell; growth; invasion; PLASMA OSTEOPONTIN; HEPATOCELLULAR-CARCINOMA; IDENTIFICATION; PROGRESSION; EXPRESSION; APOPTOSIS; CYTOKINE; MARKER; CYCLE; HEAD;
D O I：
10.3892/ol.2023.14064
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Osteopontin (OPN), a secreted phosphoglycoprotein, has important roles in tumor growth, invasion and metastasis in numerous types of cancers. Denticleless E3 ubiquitin protein ligase homolog ( DTL), one of the CUL4-DDB1-associated factors (DCAFs), has also been associated with the invasion and metastasis of cancer cells. In the present study, OPN was found to induce DTL expression in liver cancer cells, and the results obtained using luciferase activity assays demonstrated that OPN could transcriptionally activate DTL expression in liver cancer cells. Furthermore, the results of the present study demonstrated that OPN could increase the expression of DTL via PI3K/AKT signaling. In conclusion, the present study demonstrated that OPN, as an extracellular matrix protein, is able to promote the growth and invasion of liver cancer cells through stimulation of the expression of DTL via the PI3K/AKT signaling pathway.
引用
收藏
页数：10
相关论文
共 35 条
  • [1] Transcriptome profiling revealed multiple genes and ECM-receptor interaction pathways that may be associated with breast cancer
    Bao, Yulong
    Wang, Li
    Shi, Lin
    Yun, Fen
    Liu, Xia
    Chen, Yongxia
    Chen, Chen
    Ren, Yanni
    Jia, Yongfeng
    [J]. CELLULAR & MOLECULAR BIOLOGY LETTERS, 2019, 24 (1)
  • [2] MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL
    Baraniskin, Alexander
    Birkenkamp-Demtroder, Karin
    Maghnouj, Abdelouahid
    Zoellner, Hannah
    Munding, Johanna
    Klein-Scory, Susanne
    Reinacher-Schick, Anke
    Schwarte-Waldhoff, Irmgard
    Schmiegel, Wolff
    Hahn, Stephan A.
    [J]. CARCINOGENESIS, 2012, 33 (04) : 732 - 739
  • [3] Reduction of Elevated Plasma Osteopontin Levels With Resection of Non-Small-Cell Lung Cancer
    Blasberg, Justin D.
    Pass, Harvey I.
    Goparaju, Chandra M.
    Flores, Raja M.
    Lee, Suzie
    Donington, Jessica S.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (06) : 936 - 941
  • [4] Osteopontin splice variants and polymorphisms in cancer progression and prognosis
    Briones-Orta, Marco Antonio
    Erendira Avendano-Vazquez, S.
    Ivette Aparicio-Bautista, Diana
    Coombes, Jason D.
    Weber, Georg F.
    Syn, Wing-Kin
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2017, 1868 (01): : 93 - U347
  • [5] Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers
    Cao, Dong-Xing
    Li, Zhi-Jie
    Jiang, Xiao-Ou
    Lum, Yick Liang
    Khin, Ester
    Lee, Nikki P.
    Wu, Guo-Hao
    Luk, John M.
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2012, 18 (30) : 3923 - 3930
  • [6] The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease
    Chabas, D
    Baranzini, SE
    Mitchell, D
    Bernard, CCA
    Rittling, SR
    Denhardt, DT
    Sobel, RA
    Lock, C
    Karpuj, M
    Pedotti, R
    Heller, R
    Oksenberg, JR
    Steinman, L
    [J]. SCIENCE, 2001, 294 (5547) : 1731 - 1735
  • [7] Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells
    Chen, Yu-Chia
    Chen, I-shu
    Huang, Guan-Jin
    Kang, Chi-hsiang
    Wang, Kuo-Chiang
    Tsao, Min-Jen
    Pan, Hung-Wei
    [J]. ONCOTARGETS AND THERAPY, 2018, 11 : 1601 - 1616
  • [8] DTL promotes cancer progression by PDCD4 ubiquitin-dependent degradation
    Cui, Haoran
    Wang, Qin
    Lei, Zhenchuan
    Feng, Maoxiao
    Zhao, Zhongxi
    Wang, Yunshan
    Wei, Guangwei
    [J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 38 (01)
  • [9] CRL4ADTL degrades DNA-PKcs to modulate NHEJ repair and induce genomic instability and subsequent malignant transformation
    Feng, Maoxiao
    Wang, Yunshan
    Bi, Lei
    Zhang, Pengju
    Wang, Huaizhi
    Zhao, Zhongxi
    Mao, Jian-Hua
    Wei, Guangwei
    [J]. ONCOGENE, 2021, 40 (11) : 2096 - 2111
  • [10] Overexpression of c-Jun contributes to sorafenib resistance in human hepatoma cell lines
    Haga, Yuki
    Kanda, Tatsuo
    Nakamura, Masato
    Nakamoto, Shingo
    Sasaki, Reina
    Takahashi, Koji
    Wu, Shuang
    Yokosuka, Osamu
    [J]. PLOS ONE, 2017, 12 (03):
1234