Palladium-Catalyzed Direct C(sp2)-H Cyanomethylation of Arylamides using Chloroacetonitrile

被引：0

作者：

Garai, Sumit ^{[1
]}

Sureshkumar, Devarajulu ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741246, West Bengal, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 17期

关键词：

C-H BOND; ARYLATION; ALKYLATION; FUNCTIONALIZATION; COORDINATION; SILVER; ARENES; ROLES;

D O I：

10.1021/acs.joc.3c01431

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, we devised a palladium-catalyzed efficient and versatile method for C-(sp(2))-H ortho-cyanomethylation of arylamides with a broad substrate scope and moderate to excellent yields. An inexpensive and commercially available chloroacetonitrile was employed as a cyanomethylating source. This method is also compatible with the air atmosphere. Further, the synthetic feasibility of this technique is established by gram-scale synthesis and functional group transformation of the products.

引用

页码：12755 / 12764

页数：10

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