Noncoding RNA as an influential epigenetic modulator with promising roles in cancer therapeutics

被引：16

作者：

Roy, Laboni ^{[1
]}

Chatterjee, Oishika ^{[1
]}

Bose, Debopriya ^{[1
]}

Roy, Ananya ^{[1
]}

Chatterjee, Subhrangsu ^{[1
]}

机构：

[1] Bose Inst, Dept Biophys, Kolkata 700091, India

来源：

DRUG DISCOVERY TODAY | 2023年 / 28卷 / 09期

关键词：

ncRNA; lncRNA; miRNA; histone modification; DNA methylation; cancer; BREAST-CANCER; S-ADENOSYLMETHIONINE; PROSTATE-CANCER; EXPRESSION; LNCRNA; RESISTANCE; PROLIFERATION; GENE; CHEMORESISTANCE; PLURIPOTENCY;

D O I：

10.1016/j.drudis.2023.103690

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The epigenetic landscape has an important role in cellular homeostasis and its deregulation leads to cancer. Noncoding (nc)RNA networks function as major regulators of cellular epigenetic hallmarks via regulation of vital processes, such as histone modification and DNA methylation. They are integral intracellular components affecting multiple oncogenic pathways. Thus, it is important to elucidate the effects of ncRNA networks on epigenetic programming that lead to the initiation and progression of cancer. In this review, we summarize the effects of epigenetic modification influenced by ncRNA networks and crosstalk between diverse classes of ncRNA, which could aid the development of patient-specific cancer therapeutics targeting ncRNAs, thereby altering cellular epigenetics.

引用

页数：15

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