TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology

被引：20

作者：

Ort, Andres ^{[1
]}

Smallridge, John W. ^{[1
]}

Sarasso, Simone ^{[2
]}

Casarotto, Silvia ^{[2
,3
]}

von Rotz, Robin ^{[1
]}

Casanova, Andrea ^{[1
]}

Seifritz, Erich ^{[4
]}

Preller, Katrin H. ^{[1
]}

Tononi, Giulio ^{[5
]}

Vollenweider, Franz X. ^{[1
]}

机构：

[1] Univ Zurich, Psychiat Hosp, Dept Psychiat Psychotherapy & Psychosomat, Neurophenomenol Consciousness Lab, Zurich, Switzerland

[2] Univ Milan, Dept Biomed & Clin Sci, Milan, Italy

[3] IRCCS Fdn Don Carlo Gnocchi Milano, Milan, Italy

[4] Univ Zurich, Psychiat Hosp, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland

[5] Univ Wisconsin, Dept Psychiat, Madison, WI USA

来源：

ISCIENCE | 2023年 / 26卷 / 05期

基金：

欧盟地平线“2020”;

关键词：

PSILOCYBIN; CONNECTIVITY; NETWORK; BRAIN; PSYCHEDELICS; INHIBITION; EXPERIENCE; DEFICITS; HUMANS; DEPEND;

D O I：

10.1016/j.isci.2023.106589

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Exploring the neurobiology of the profound changes in consciousness induced by classical psychedelic drugs may require novel neuroimaging methods. Serotonergic psychedelic drugs such as psilocybin produce states of increased sensory-emotional awareness and arousal, accompanied by increased spontaneous electroencephalo-graphic (EEG) signal diversity. By directly stimulating cortical tissue, the altered dy-namics and propagation of the evoked EEG activity can reveal drug-induced changes in the overall brain state. We combine Transcranial Magnetic Stimulation (TMS) and EEG to reveal that psilocybin produces a state of increased chaotic brain activity which is not a result of altered complexity in the underlying causal interac-tions between brain regions. We also map the regional effects of psilocybin on TMS-evoked activity and identify changes in frontal brain structures that may be associated with the phenomenology of psychedelic experiences.

引用

页数：17

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