Pegriseofamines A-E: Five cyclopiazonic acid related indole alkaloids from the fungus Penicillium griseofulvum

被引：7

作者：

Liang, Yu ^{[1
]}

Liao, Hong ^{[1
]}

Chen, Xuanni ^{[1
]}

Wang, Qiwei ^{[1
]}

Li, Qin ^{[1
]}

Shen, Yong ^{[1
]}

Zheng, Yuyi ^{[1
]}

Li, Xiao-Nian ^{[2
]}

Zhu, Hucheng ^{[1
]}

Li, Dongyan ^{[3
]}

Sun, Weiguang ^{[1
]}

Chen, Chunmei ^{[1
]}

Zhang, Yonghui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Chi, Kunming 650204, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430030, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2023年 / 136卷

关键词：

Penicillium griseofulvum; Alkaloid; Cyclopiazonic acid; Immunosuppression activity;

D O I：

10.1016/j.bioorg.2023.106553

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five new cyclopiazonic acid related indole alkaloids, pegriseofamines A-E (1-5), were isolated from the fungus Penicillium griseofulvum. Their structures and absolute configurations were determined by NMR, HRESIMS, quantum-chemical calculation, and X-ray diffraction experiments. Among them, pegriseofamine A (1) possesses an undescribed 6/5/6/7 tetracyclic ring system generated by the fusion of an azepine and an indole unit via a cyclohexane, and the postulated biosynthetic origin of 1 was discussed. Compound 4 could relieve liver injury and prevent hepatocyte apoptosis in ConA-induced autoimmune liver disease.

引用

页数：9

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