Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development

被引：4

作者：

Song, Yuhan ^{[1
,4
]}

Song, Fujie ^{[2
,3
]}

Xiao, Xuan ^{[1
,4
]}

Song, Zhifeng ^{[1
,4
,5
]}

Liu, Shangfeng ^{[4
,6
]}

机构：

[1] Fudan Univ, Shanghai Stomatol Hosp, Dept Oral Mucosa, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Dept Dent Clin 1, Shanghai Peoples Hosp 9, Sch Med,Coll Stomatol, Shanghai, Peoples R China

[3] Natl Clin Res Ctr Oral Dis, Natl Ctr Stomatol, Shanghai Key Lab Stomatol, Shanghai, Peoples R China

[4] Fudan Univ, Shanghai Stomatol Hosp, Shanghai Key Lab Craniomaxillofacial Dev & Dis, Shanghai, Peoples R China

[5] Fudan Univ, Shanghai Stomatol Hosp, Dept Oral Mucosa, Shanghai 200031, Peoples R China

[6] Fudan Univ, Shanghai Stomatol Hosp, Shanghai Key Lab Craniomaxillofacial Dev & Dis, Shanghai 200001, Peoples R China

来源：

ORGANOGENESIS | 2023年 / 19卷 / 01期

基金：

上海市自然科学基金;

关键词：

Early tooth development; expression patterns; RNA-seq; tooth agenesis; Wnt signaling pathway; MUTATIONS; VARIANTS; AGENESIS; MODULATION; GENOTYPE; APC;

D O I：

10.1080/15476278.2023.2212583

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is known to all that Wnt signaling pathway plays an important role in the early development of tooth. Our previous research found that Wnt signaling pathway played crucial roles in dental development, and mutations in antagonist of Wnt signaling pathway may lead to the formation of supernumerary teeth. However, the expression pattern of Wnt signaling molecules in early development of tooth, especially genes with stage specificity, remains unclear. Hence, we applied RNA-seq analysis to determine the expression levels of wnt signal molecules at five different stages of rat first molar tooth germ. In addition, after literature review we summarized the function of Wnt signaling molecules during tooth development and the relationship between Wnt signaling molecules variation and tooth agenesis. Our research may have implications for exploring the role of Wnt signaling molecules in different stages of tooth development.

引用

页数：12

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