Helicobacter Pylori Virulence Factor Cytotoxin-Associated Gene A (CagA) Induces Vascular Calcification in Coronary Artery Smooth Muscle Cells

被引：5
|
作者：
Sundqvist, Martin O. O. [1 ,2 ]
Warme, Jonatan [1 ,2 ]
Hofmann, Robin [1 ,2 ]
Pawelzik, Sven-Christian [3 ,4 ]
Back, Magnus [3 ,4 ]
机构：
[1] Karolinska Inst, Dept Clin Sci & Educ, Div Cardiol, Sodersjukhuset, SE-11883 Stockholm, Sweden
[2] Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden
[3] Karolinska Inst, Dept Med Solna, Translat Cardiol, SE-17177 Stockholm, Sweden
[4] Karolinska Univ Hosp, Heart & Vasc Ctr, Dept Cardiol, SE-17176 Stockholm, Sweden
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 06期
基金：
瑞典研究理事会;
关键词：
vascular calcification; Helicobacter pylori; cytotoxin-associated gene A; coronary artery smooth muscle cells; cardiovascular disease; CARDIOVASCULAR-DISEASE; CALCIUM SCORE; ATHEROSCLEROSIS; INFECTION; SEROPOSITIVITY; PATHOGENESIS; ANTIBODIES; RISK;
D O I：
10.3390/ijms24065392
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Helicobacter pylori (H. pylori) has been associated with cardiovascular diseases. The pro-inflammatory H. pylori virulence factor cytotoxin-associated gene A (CagA) has been detected in serum exosomes of H. pylori-infected subjects and may exert systemic effects throughout the cardiovascular system. The role of H. pylori and CagA in vascular calcification was hitherto unknown. The aim of this study was to determine the vascular effects of CagA through human coronary artery smooth muscle cell (CASMC) osteogenic and pro-inflammatory effector gene expression as well as interleukin 1 beta secretion and cellular calcification. CagA upregulated bone morphogenic protein 2 (BMP-2) associated with an osteogenic CASMC phenotype switch and induced increased cellular calcification. Furthermore, a pro-inflammatory response was observed. These results support that H. pylori may contribute to vascular calcification through CagA rendering CASMCs osteogenic and inducing calcification.
引用
收藏
页数：12
相关论文
共 50 条
  • [21] A novel role for Helicobacter pylori cytotoxin-associated gene A in negative regulation of autophagy in human gastric cells
    Akihiko Sakatani
    Yoshito Hayashi
    Hirotsugu Saiki
    Minoru Kato
    Ryotaro Uema
    Takanori Inoue
    Keiichi Kimura
    Shunsuke Yoshii
    Yoshiki Tsujii
    Shinichiro Shinzaki
    Hideki Iijima
    Tetsuo Takehara
    BMC Gastroenterology, 23
  • [22] Helicobacter pylori cytotoxin-associated gene-A antibodies do not predict complications or death in type 2 diabetes: The Fremantle Diabetes Study
    Schimke, Katrin
    Chubb, Stephen A. P.
    Davis, Wendy A.
    Davis, Timothy M. E.
    ATHEROSCLEROSIS, 2010, 212 (01) : 321 - 326
  • [23] Cytotoxin-associated gene A and vacuolating cytotoxin A in human isolates of Helicobacter pylori and their association with the clinical status of ulcer disease
    Carattoli, A
    Pezzella, C
    Pietroiusti, A
    Galante, A
    Pezzotti, P
    Luzzi, I
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2000, 12 (11) : 1207 - 1213
  • [24] Relationship between Helicobacter pylori cytotoxin-associated gene A protein with clinical outcomes in patients with rheumatoid arthritis
    Ebrahimi, Aliasghar
    Soofizadeh, Babak
    Ebrahimi, Faegheh
    Moaadab, Seyed Yagoob
    Bonyadi, Mohammadreza
    Gojazadeh, Morteza
    Mahdavi, Aida Malek
    IMMUNOLOGY LETTERS, 2019, 211 : 49 - 52
  • [25] G-protein-coupled estrogen receptor prevents nuclear factor-kappa B promoter activation by Helicobacter pylori cytotoxin-associated gene A in gastric cancer cells
    Okamoto, Mariko
    Miura, Atsushi
    Ito, Ryota
    Kamada, Toshiki
    Mizukami, Yoichi
    Kawamoto, Keiko
    JOURNAL OF VETERINARY MEDICAL SCIENCE, 2023, 85 (12) : 1348 - 1354
  • [26] Association between cerebral ischemia and cytotoxin-associated gene-A-bearing strains of Helicobacter pylori
    Preusch, MR
    Grau, AJ
    Buggle, F
    Lichy, C
    Bartel, J
    Black, C
    Rudi, J
    STROKE, 2004, 35 (08) : 1800 - 1804
  • [27] Effects of cytotoxin-associated gene A (CagA) positive Helicobacter pylori infection on anti-platelet glycoprotein antibody producing B cells in patients with primary idiopathic thrombocytopenic purpura (ITP)
    Cheng, Yuan-Shan
    Kuang, Li-Ping
    Zhuang, Chun-Lan
    Jiang, Jia-Dian
    Shi, Man
    PAKISTAN JOURNAL OF MEDICAL SCIENCES, 2015, 31 (01) : 121 - 126
  • [28] The Relationship between Gastroduodenal Pathologies and Helicobacter pylori cagL (Cytotoxin-Associated Gene L) Polymorphism
    Ozbey, Dogukan
    Demiryas, Suleyman
    Akkus, Seher
    Kepil, Nuray
    Dinc, Harika Oyku
    Gareayaghi, Nesrin
    Demirci, Mehmet
    Kurt, Enes Ali
    Uysal, Omer
    Saribas, Suat
    Tokman, Hrisi Bahar
    Kocazeybek, Bekir
    TURKISH JOURNAL OF GASTROENTEROLOGY, 2023, 34 (04) : 346 - +
  • [29] Helicobacter pylori cytotoxin-associated gene A genotype in Egyptian patients with Parkinson’s disease: could eradication benefit?
    Mashaly M.
    Saudy N.
    Belal T.
    Motawei S.
    Comparative Clinical Pathology, 2017, 26 (4) : 893 - 900
  • [30] Increased seropositivity of Helicobacter pylori cytotoxin-associated gene-A in Behçet’s disease
    Teoman Zafer Apan
    Ragıp Gürsel
    Alp Dolgun
    Clinical Rheumatology, 2007, 26 : 885 - 889
12345