Effect of radiation exposure on survival after first solid cancer diagnosis in A-bomb survivors

被引:0
作者
Sposto, Richard [1 ,4 ]
Sugiyama, Hiromi [2 ]
Tsuruyama, Tatsuaki [3 ]
Brenner, Alina, V [2 ]
机构
[1] Radiat Effects Res Fdn, Dept Stat, Hiroshima, Japan
[2] Radiat Effects Res Fdn, Dept Epidemiol, Hiroshima, Japan
[3] Radiat Effect Res Fdn, Dept Mol Biosci, Hiroshima, Japan
[4] Radiat Effects Res Fdn, Dept Stat, 5-2 Hijiyama Pk,Minami Ku, Hiroshima 7320815, Japan
关键词
A-bomb radiation; Cancer; Post-diagnosis survival;
D O I
10.1016/j.canep.2023.102341
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Comparison of the estimated effect of atomic bomb radiation exposure on solid cancer incidence and solid cancer mortality in the RERF Life Span Study (LSS) reveals a difference in the magnitude and shape of the excess relative risk dose response. A possible contributing factor to this difference is pre-diagnosis radiation effect on post-diagnosis survival. Pre-diagnosis radiation exposure theoretically could influence post-diagnosis survival by affecting the genetic makeup and possibly aggressiveness of cancer, or by compromising tolerance for aggressive treatment for cancer.Methods: We analyze the radiation effect on post-diagnosis survival in 20,463 LSS subjects diagnosed with first-primary solid cancer between 1958 and 2009 with particular attention to whether death was caused by the first-primary cancer, other cancer, or non-cancer diseases.Results: From multivariable Cox regression analysis of cause-specific survival, the excess hazard at 1 Gy (EH1Gy) for death from the first primary cancer was not significantly different from zero - p = 0.23, EH1Gy = 0.038 (95 % CI:-0.023, 0.104). Death from other cancer and death from non-cancer diseases both were significantly asso-ciated with radiation dose: other cancer EH1Gy = 0.38 (95 % CI: 0.24, 0.53); non-cancer EH1Gy = 0.24 (95 % CI: 0.13, 0.36), both p < 0.001.Conclusion: There is no detectable large effect of pre-diagnosis radiation exposure on post-diagnosis death from the first primary cancer in A-bomb survivors.Impact: A direct effect of pre-diagnosis radiation exposure on cancer prognosis is ruled out as an explanation for the difference in incidence and mortality dose response in A-bomb survivors.
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页数:6
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