Acceptor-donor-acceptor structured phototheranostics for near-infrared II fluorescent and photoacoustic imaging-guided photodynamic and photothermal synergistic therapy

被引：19

作者：

Li, Baoling ^{[1
]}

Gan, Yabing ^{[3
]}

Yang, Ke ^{[1
]}

Pang, E. ^{[1
]}

Ren, Xiaojie ^{[4
,5
]}

Zhao, Shaojing ^{[1
]}

He, Dan ^{[1
]}

Zhao, Fuwen ^{[2
]}

Wang, Benhua ^{[1
]}

Yin, Peng ^{[3
]}

Song, Xiangzhi ^{[1
]}

Lan, Minhuan ^{[1
]}

机构：

[1] Cent South Univ, Coll Chem & Chem Engn, Key Lab Hunan Prov Water Environm & Agr Prod Safe, Changsha 410083, Peoples R China

[2] Cent South Univ, State Key Lab Powder Met, Changsha 410083, Peoples R China

[3] Hunan Normal Univ, Key Lab Chem Biol & Tradit Chinese Med Res, Key Lab Assembly & Applicat Organ Funct Mol Hunan, Minist Educ, Changsha 410083, Peoples R China

[4] City Univ Hong Kong, Dept Chem, Hong Kong, Peoples R China

[5] City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Hong Kong, Peoples R China

来源：

SCIENCE CHINA-MATERIALS | 2023年 / 66卷 / 01期

基金：

中国国家自然科学基金;

关键词：

acceptor-donor-acceptor structure; near-infrared II fluorescence; photoacoustic imaging; photodynamic therapy; photothermal therapy;

D O I：

10.1007/s40843-022-2143-2

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Multi-modal imaging-guided synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) show great benefits in cancer treatment. The phototheranostics with near-infrared (NIR) absorption, high reactive oxygen species (ROS) generation and photothermal conversion efficiency is highly desirable. Here, we designed and synthesized an "acceptor-donor-acceptor" (A-D-A) structured molecule named IDCIC, with strong absorbance in the NIR region. We further prepared IDCIC into water-soluble nanoparticles (NPs) by wrapping with 1,2-distearoylsn-glycero-3-phosphoethanolamine-N-Rpolyethylene glycol)-2000]-amine (DSPE-PEG2000-NH2). The obtained IDCIC NPs show an NIR absorption peak at 760 nm and an NIR-II fluorescence spectrum peak at similar to 1000 nm with a fluorescent quantum yield of 1.2%, enabling them excellent photoacoustic and NIR-II fluorescent imaging capabilities. Moreover, IDCIC NPs could simultaneously generate singlet oxygen (with a quantum yield of 9.1%), hydroxyl radicals (center dot OH) and heat (with a photothermal conversion efficiency of 78.9%) under 808-nm laser irradiation. Based on the above-mentioned properties, IDCIC NPs were used for dual-modal imaging-guided synergistic photodynamic/photothermal therapy of cancer.

引用

页码：385 / 394

页数：10

共 41 条

[21] Molecular Design of Highly Efficient Heavy-Atom-Free Triplet BODIPY Derivatives for Photodynamic Therapy and Bioimaging [J].