Identification and α-glucosidase inhibitory activity evaluation of two new coumarins derived from Mansonia gagei J. R. Drumm.

被引：1

作者：

Le, Huong Thi Thu ^{[1
]}

Hioki, Yusuke ^{[2
]}

Nguyen, Duy Vu ^{[3
]}

Le, Thi-Kim-Dung ^{[4
,5
]}

Nguyen, Van-Kieu ^{[6
,7
]}

Dang, Tien T. ^{[8
]}

Nguyen, Thi-Anh-Tuyet ^{[1
]}

Nguyen, Thi-Hoai-Thu ^{[9
]}

Vu, Thi-Hai-Duyen ^{[1
]}

Pham, Thi-Kim-Ngan ^{[10
]}

Kita, Masaki ^{[2
]}

Chavasiri, Warinthorn ^{[3
,11
]}

机构：

[1] Ho Chi Minh City Univ Educ, Dept Chem, Ho Chi Minh City, Vietnam

[2] Nagoya Univ, Grad Sch Bioagr Sci, Nagoya, Japan

[3] Chulalongkorn Univ, Fac Sci, Ctr Excellence Nat Prod Chem, Dept Chem, Bangkok, Thailand

[4] Ton Duc Thang Univ, Inst Adv Study Technol, Lab Biophys, Ho Chi Minh City, Vietnam

[5] Ton Duc Thang Univ, Fac Pharm, Ho Chi Minh City, Vietnam

[6] Duy Tan Univ, Inst Fundamental & Appl Sci, Ho Chi Minh City, Vietnam

[7] Duy Tan Univ, Fac Nat Sci, Da Nang, Vietnam

[8] Vietnam Acad Sci & Technol, Inst Appl Mat Sci, Ho Chi Minh City, Vietnam

[9] Univ Med & Pharm Ho Chi Minh City, Fac Basic Sci, Ho Chi Minh City, Vietnam

[10] Educ & Training Dept Lang Son Prov, Lang Son City, Vietnam

[11] Chulalongkorn Univ, Fac Sci, Dept Chem, Nanotec CU Ctr Excellence Food & Agr, Bangkok, Thailand

来源：

NATURAL PRODUCT RESEARCH | 2024年

关键词：

Mansonia gagei; coumarin; alpha-glucosidase inhibitory activity; DIHYDROCOUMARINS;

D O I：

10.1080/14786419.2024.2324367

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Five coumarins were isolated from the heartwood of Mansonia gagei, which included two newly discovered compounds, namely 11-hydroxypopulene E (1) and mansorin D (2), along with three previously identified compounds. The structures were determined through the utilisation of comprehensive spectroscopic data, ECD calculations, and a thorough comparison with existing literature data. The alpha-glucosidase inhibitory activities of all isolated compounds were assessed in yeast. Out of the compounds tested, compound 2 exhibited the most significant activity, displaying a percentage inhibition of 34.33% at a concentration of 200 mu M.

引用

页数：6

共 21 条

[1] Anticancer Profiling for Coumarins and Related O-Naphthoquinones from Mansonia gagei against Solid Tumor Cells In Vitro
Baghdadi, Mohammed A.
Al-Abbasi, Fahad A.
El-Halawany, Ali M.
Aseeri, Ali H.
Al-Abd, Ahmed M.
[J]. MOLECULES, 2018, 23 (05):
[2] Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea
Boonsri, Sompong
Karalai, Chatchanok
Ponglimanont, Chanita
Chantrapromma, Suchada
Kanjana-opas, Akkharawit
[J]. JOURNAL OF NATURAL PRODUCTS, 2008, 71 (07): : 1173 - 1177
[3] Bruhn T., 2017, SpecDis
[4] Anti-estrogenic activity of mansorins and mansonones from the heartwood of Mansonia gagei DRUMM.
El-Halawany, All Mahmoud
Chung, Mi Hwa
Ma, Chao-Mei
Komatsua, Katsuko
Nishihara, Tsutornu
Hattori, Masao
[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (09) : 1332 - 1337
[5] Frisch M. ea., 2016, GAUSSIAN 16 REVISION
[6] Halgren TA, 1996, J COMPUT CHEM, V17, P490, DOI [10.1002/(SICI)1096-987X(199604)17:5/6<616::AID-JCC5>3.0.CO
[7] 2-X, 10.1002/(SICI)1096-987X(199604)17:5/6<490::AID-JCC1>3.0.CO
[8] 2-P]
[9] α-Glucosidase inhibition of sesquiterpenoids from the heartwood of Mansonia gagei
Le, Huong Thi Thu
Hioki, Yusuke
Danova, Ade
Nguyen, Van-Kieu
Duong, Thuc-Huy
Kita, Masaki
Chavasiri, Warinthorn
[J]. PHYTOCHEMISTRY, 2023, 213
[10] MOE, 2021, 2019.01. Chemical Computing Group ULC, 1010 Sherbooke St. West, Suite # 910

← 1 2 3 →