Intestinal organoid technology and applications in probiotics

被引：3
作者：
Tan, Han [1 ]
Chen, Xiaoyong [1 ,2 ,3 ,4 ]
Wang, Chen [1 ,2 ,3 ,4 ]
Song, Jiajia [1 ,2 ,3 ,4 ]
Xu, Jiahui [1 ]
Zhang, Yuhong [5 ]
Suo, Huayi [1 ,2 ,3 ,4 ]
机构：
[1] Southwest Univ, Coll Food Sci, Chongqing, Peoples R China
[2] Chongqing Agr Prod Proc Technol Innovat Platform, Chongqing, Peoples R China
[3] Chongqing Key Lab Special Food Cobuilt Sichuan & C, Chongqing, Peoples R China
[4] Southwest Univ, Citrus Res Inst, Natl Citrus Engn Res Ctr, Chongqing, Peoples R China
[5] Tibet Acad Agr & Anim Husb Sci, Inst Food Sci & Technol, Lhasa, Peoples R China
来源：
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2025年 / 65卷 / 06期
关键词：
Intestinal organoid; probiotic; intestinal health; probiotic mechanisms; intestinal microbiota; CHAIN FATTY-ACIDS; CIRCADIAN CLOCK GENE; LONG-TERM EXPANSION; STEM-CELLS; IN-VITRO; EPITHELIAL-CELLS; HUMAN COLON; GUT; MODEL; DISEASE;
D O I：
10.1080/10408398.2023.2288887
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The impacts of probiotics on maintaining the host's intestinal health have been extensively confirmed. Organoid technology revolutionizes intestinal health research by providing a unique platform to study the effects of probiotics. It overcomes challenges posed by animal models and 2D cell models in accurately simulating the in vivo environment. This review summarizes the development of intestinal organoid technology and its potential applications in intestinal health research as well as highlights the regulatory mechanisms of probiotics on intestinal health, which have been revealed using intestinal organoid technology. Furthermore, an overview of its potential applications in probiotic research has also been provided. This review aims to improve the understanding of intestinal organoid technology's applications in this field as well as to contribute to its further development. [GRAPHICS] .
引用
收藏
页码：1055 / 1069
页数：15
相关论文
共 105 条
  • [1] Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration
    Abo, Hirohito
    Chassaing, Benoit
    Harusato, Akihito
    Quiros, Miguel
    Brazil, Jennifer C.
    Ngo, Vu L.
    Viennois, Emilie
    Merlin, Didier
    Gewirtz, Andrew T.
    Nusrat, Asma
    Denning, Timothy L.
    [J]. NATURE COMMUNICATIONS, 2020, 11 (01)
  • [2] Host-microbiome interactions: Gut-Liver axis and its connection with other organs
    Anand, Swadha
    Mande, Sharmila S.
    [J]. NPJ BIOFILMS AND MICROBIOMES, 2022, 8 (01)
  • [3] Gut Microbiota-Derived Propionate Regulates the Expression of Reg3 Mucosal Lectins and Ameliorates Experimental Colitis in Mice
    Bajic, Danica
    Niemann, Adrian
    Hillmer, Anna-Katharina
    Mejias-Luque, Raquel
    Bluemel, Sena
    Docampo, Melissa
    Funk, Maja C.
    Tonin, Elena
    Boutros, Michael
    Schnabl, Bernd
    Busch, Dirk H.
    Miki, Tsuyoshi
    Schmid, Roland M.
    van den Brink, Marcel R. M.
    Gerhard, Markus
    Stein-Thoeringer, Christoph K.
    [J]. JOURNAL OF CROHNS & COLITIS, 2020, 14 (10) : 1462 - 1472
  • [4] Advancing intestinal organoid technology to decipher nano-intestine interactions and treat intestinal disease
    Bao, Lin
    Cui, Xuejing
    Bai, Ru
    Chen, Chunying
    [J]. NANO RESEARCH, 2023, 16 (03) : 3976 - 3990
  • [5] In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection
    Bartfeld, Sina
    Bayram, Tulay
    van de Wetering, Marc
    Huch, Meritxell
    Begthel, Harry
    Kujala, Pekka
    Vries, Robert
    Peters, Peter J.
    Clevers, Hans
    [J]. GASTROENTEROLOGY, 2015, 148 (01) : 126 - U554
  • [6] Microfluidic organs-on-chips
    Bhatia, Sangeeta N.
    Ingber, Donald E.
    [J]. NATURE BIOTECHNOLOGY, 2014, 32 (08) : 760 - 772
  • [7] Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
    Boj, Sylvia F.
    Vonk, Annelotte M.
    Statia, Marvin
    Su, Jinyi
    Vries, Robert R. G.
    Beekman, Jeffrey M.
    Clevers, Hans
    [J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2017, (120):
  • [8] Suspension culture promotes serosal mesothelial development in human intestinal organoids
    Capeling, Meghan M.
    Huang, Sha
    Childs, Charlie J.
    Wu, Joshua H.
    Tsai, Yu-Hwai
    Wu, Angeline
    Garg, Neil
    Holloway, Emily M.
    Sundaram, Nambirajan
    Bouffi, Carine
    Helmrath, Michael
    Spence, Jason R.
    [J]. CELL REPORTS, 2022, 38 (07):
  • [9] A three-dimensional model of human lung development and disease from pluripotent stem cells
    Chen, Ya-Wen
    Huang, Sarah Xuelian
    Rodrigues Toste de Carvalho, Ana Luisa
    Ho, Siu-Hong
    Islam, Mohammad Naimul
    Volpi, Stefano
    Notarangelo, Luigi D.
    Ciancanelli, Michael
    Casanova, Jean-Laurent
    Bhattacharya, Jahar
    Liang, Alice F.
    Palermo, Laura M.
    Porotto, Matteo
    Moscona, Anne
    Snoeck, Hans-Willem
    [J]. NATURE CELL BIOLOGY, 2017, 19 (05) : 542 - +
  • [10] Modeling Development and Disease with Organoids
    Clevers, Hans
    [J]. CELL, 2016, 165 (07) : 1586 - 1597
12345678910